PLA2R1 / PLA2R antibody

Principal name

PLA2R1 / PLA2R antibody

Alternative names for PLA2R1 / PLA2R antibody

PLA2-R, CLEC13C, M-type receptor, Secretory phospholipase A2 receptor, 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C

SwissProt ID

P49259 (Bovin), Q13018 (Human), Q62028 (Mouse)

Gene ID

22925 (PLA2R1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Por (Porcine)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of PLA2R1 / PLA2R antibody

PLA2R is a receptor for secretory phospholipase A2 (sPLA2). It acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. It is also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. PLA2R may be involved in responses in proinflammatory cytokine productions during endotoxic shock. It also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLA2R1 / PLA2R antibody

(1ug/ml) staining of Human Ileum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLA2R1 / PLA2R antibody

PLA2R1 / PLA2R Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PLA2R1 / PLA2R antibody

PLA2R1 / PLA2R Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PLA2R1 / PLA2R antibody

Immunohistochemistry-Paraffin: PLA2R1 Antibody [NBP1-84449] Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in a subset of cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PLA2R1 / PLA2R (transcript variant 2)

PLA2R1 / PLA2R Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PLA2R1 overexpression lysate

PLA2R1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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