Platelet glycoprotein VI antibody

Principal name

Platelet glycoprotein VI antibody

Alternative names for Platelet glycoprotein VI antibody

GP6, GPVI, Glycoprotein 6

SwissProt ID

P0C191 (Mouse), Q9HCN6 (Human)

Gene ID

51206 (GP6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of Platelet glycoprotein VI antibody

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].

General readings

1. Jarvis GE, Atkinson BT, Snell DC, et al. Distinct roles of GPVI and integrin alpha(2) beta(1) in platelet shape change and aggregation induced by different collagens. Br. J. Pharmacol. 2002; 137:107-17.
2. Inoue O, Suzuki-Inoue K, Dean WL, et al. Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J. Cell Biol. 2003;160:769-80.
3. Clemetson JM, Polgar J, Magnenat E, et al. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to Fc?R and the natural killer receptors. J Biol. Chem. 1999; 274:29019-24.
4. Jandrot-Perrus M, Busfield S, Lagrue AH, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood 2000; 96:1798-807.
5. Massberg S, Gawaz M, Gurner S, et al. A crucial role of
glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J. Exp. Med. 2003; 197:41-9.

11 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Platelet glycoprotein VI (C-term) antibody

  Rabbit Polyclonal GPVI Antibody  
Western blot analysis of GPVI in A20 lysate with GPVI antibody at 1ug/ml in either the absence or (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Platelet glycoprotein VI (Center) antibody

  Rabbit Polyclonal GPVI Antibody  
Western blot analysis of GPVI in A-20 lysate with GPVI antibody at 1µg/ml in either the absence or (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Platelet glycoprotein VI antibody

  Rabbit Polyclonal Anti-GP6 Antibody  
WB Suggested Anti-GP6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Platelet glycoprotein VI antibody

Western blot analysis of GP6 expression in Jurkat cell lysate ( Lane 1, 2 ) . The antibody recognizes ~58 kDa human GPVI. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Platelet glycoprotein VI antibody

Western blot analysis of GP6 in A-20 lysate with GP6 polyclonal antibody ( Cat # PAB13394 ) at 1µg/m in either the absence or ( B ) the presence of blocking peptide. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Platelet glycoprotein VI antibody

Western blot analysis of GP6 in mouse brain lysate with GP6 polyclonal antibody ( Cat # PAB13395 ) at 1µg/ml in either the absence or ( B ) the presence of blocking peptide. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Platelet glycoprotein VI antibody

Human Jurkat; WB Suggested Anti-GP6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Jurkat cell lysate; GP6 antibody - middle region (ARP47248_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GP6 (mGFP-tagged)-Human glycoprotein VI (platelet) (GP6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GP6 (mGFP-tagged)-Human glycoprotein VI (platelet) (GP6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,270.00
  OriGene Technologies, Inc.

Lenti ORF particles, GP6 (mGFP-tagged) - Human glycoprotein VI (platelet) (GP6), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, GP6 (mGFP-tagged) - Human glycoprotein VI (platelet) (GP6), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GP6 (Myc-DDK-tagged)-Human glycoprotein VI (platelet) (GP6), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GP6 (Myc-DDK-tagged)-Human glycoprotein VI (platelet) (GP6), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, GP6 (Myc-DDK tagged) - Human glycoprotein VI (platelet) (GP6), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GP6 (Myc-DDK tagged) - Human glycoprotein VI (platelet) (GP6), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

11 Item(s)

per page
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