PLCG2 antibody

Principal name

PLCG2 antibody

Alternative names for PLCG2 antibody

Phospholipase C-gamma-2, PLC-gamma-2, Phospholipase C-IV, PLC-IV, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2, Phosphoinositide phospholipase C-gamma-2

SwissProt ID

P16885 (Human), P24135 (Rat), Q8CIH5 (Mouse)

Gene ID

5336 (PLCG2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of PLCG2 antibody

Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane sigling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). At least four families of PLCs have been identified: PLCß, PLC?, PLCd and PLCe. The PLCß subfamily includes four members, PLCß1-4. All four members of the subfamily are activated by a- or ß-?-subunits of the heterotrimeric G-proteins.Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCß3 activity . Ser537 of PLCß3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCß3. PLC? is activated by both receptor and nonreceptor tyrosine kises .PLC? forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLC? at Tyr771, 783 and 1245. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLC?1. PLC?2 is engaged in antigen-dependent sigling in B cells and collagen-dependent sigling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197 and 1217 is correlated with PLC?2 activity.

General readings

Yue, C. et al. (1998) J. Biol. Chem. 273, 18023-18027.
Yue, C. et al. (2000) J. Biol. Chem. 275, 30220-30225.
Margolis, B. et al. (1989) Cell 57, 1101-1107.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLCG2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between PIK3R1 and PLCG2 HeLa cells were stained with anti-PIK3R1 rabbit purified polyclonal 1:1200 and anti-PLCG2 mouse purified polyclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PLCG2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between PLCG2 and PLCG1 HeLa cells were stained with anti-PLCG2 rabbit purified polyclonal 1:1200 and anti-PLCG1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PLCG2 (1213-1232) antibody

Human Hodgkin's lymphoma stained with Anti-PLC γ2, cat# AP15735PU Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

PLCG2 (1213-1232) antibody

Human Hodgkin's lymphoma stained with Anti-PLC γ2, cat# AP15735PU Rabbit Purified Hu, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

PLCG2 (1213-1232) antibody

Human Hodgkin's lymphoma stained with Anti-PLC γ2, cat# AP15735PU Rabbit Purified Hu, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

PLCG2 antibody

Predicted band size: 150 kDa . Positive control: Ramos cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLCG2 antibody

Predicted band size: 148 kDa . Positive control: 293 and 3T3 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2: 293 and 3T3 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLCG2 antibody

Western blot analysis of extracts of various cell lines, using PLCG2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLCG2 antibody

Western blot analysis of PLCG2 expression in COLO205 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PLCG2 antibody

PLCG2 Rabbit Aff - Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

PLCG2 control peptide

PLCG2 Purified
50 µg / €190.00
  Acris Antibodies GmbH

PLCG2 antibody

Western blot analysis of PLCγ2 expression in Jurkat cell lysate. Rabbit Aff - Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

PLCG2 pTyr753 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using PLCG2 antibody  (phospho-Tyr753) Cat.-No. AP02452PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

PLCG2 pTyr753 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using PLCG2 antibody  (phospho-Tyr753) Cat.-No. AP02452PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

PLCG2 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using PLCG2 antibody AP02700PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

PLCG2 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using PLCG2 antibody AP02700PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

PLCG2 antibody

Immunohistochemistry (IHC) analyzes of PLCG2 antibody (Cat.-No.: AP06406PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PLCG2 antibody

Immunohistochemistry (IHC) analyzes of PLCG2 antibody (Cat.-No.: AP06571PU-N) in paraffin-embedded human breast tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PLCG2 pTyr1217 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLC-gamma 2 (phospho-Tyr1217) Antibody AP08037PU. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 ml / €320.00
  Acris Antibodies GmbH

PLCG2 pTyr1217 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLC-gamma 2 (phospho-Tyr1217) Antibody AP08037PU. Rabbit Aff - Purified Hu, Ms, Rt P
50 µl / €240.00
  Acris Antibodies GmbH

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