PLCZ1 antibody

Principal name

PLCZ1 antibody

Alternative names for PLCZ1 antibody

Phospholipase C-zeta-1, Phospholipase C zeta 1, PLC-zeta-1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1

SwissProt ID

Q1RML2 (Bovin), Q2VRL0 (Chick), Q5FX52 (Rat), Q7YRU3 (Pig), Q86YW0 (Human), Q8K4D7 (Mouse)

Gene ID

89869 (PLCZ1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of PLCZ1 antibody

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

General readings

Claire Young B.S.et al. Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.Fertility and Sterility.May 2009,Volume 91, Issue 5, Supplement 1, Pages 2230-2242.

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLCZ1 antibody

PLCZ1 Rabbit Serum Hu E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PLCZ1 antibody

Immunohistochemistry-Paraffin: PLCZ1 Antibody [NBP1-80982] Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferus ducts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

2 Item(s)

per page
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