Alternative names for PLCZ1 antibody
Phospholipase C-zeta-1, Phospholipase C zeta 1, PLC-zeta-1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1
Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)
Background of PLCZ1 antibody
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Claire Young B.S.et al. Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.Fertility and Sterility.May 2009,Volume 91, Issue 5, Supplement 1, Pages 2230-2242.