Pleiotrophin / PTN antibody

Principal name

Pleiotrophin / PTN antibody

Alternative names for Pleiotrophin / PTN antibody

HBNF1, HBNF-1, NEGF1, HBBM, HBGF-8, HB-GAM, OSF1, OSF-1, Heparin-binding brain mitogen, Heparin-binding growth factor 8, Heparin-binding growth-associated molecule, Heparin-binding neurite outgrowth-promoting factor 1, Osteoblast-specific factor 1

SwissProt ID

P21246 (Human), P21782 (Bovin), P32760 (Chick), P63089 (Mouse), P63090 (Rat), P79281 (Pig)

Gene ID

5764 (PTN), 19242 (Ptn), 24924

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of Pleiotrophin / PTN antibody

Pleiotrophin (Osteoblast-Specific Factor-1, OSF-1) contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues); lysine cluster sequences are found in the N-terminal and Cterminal ends of the structure. The OSF-1 gene was shown by Northern blotting analysis to be expressed in mouse calvarial osteoblastenriched cells and in mouse brain tissues, but not in thymus, spleen, kidney, liver, lung, testis or heart. Pliotrophin has the ability to promote adhesion, migration, expansion, and differentiation of human osteoprogenitor cells. In addition to certain types of cancer, the embryonic growth and differentiation factor pleiotrophin is found also in adults in inflammatory diseases. In osteoarthritis, pleiotrophin is especially expressed in early stages, and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in cartilage
repair in osteoarthritis, in particular, in earlier stages.
Total 152 AA. MW: 17.3 kDa. N-Terminal His-tag and thrombin cleavage site 16 AA (highlighted).

General readings

Li, F., et al. J. Biol. Chem. 285(36): 27673-27685 (2010)
Dos Santos, C., et al. Int. J. Cancer 127(5): 1038-1051 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8): 247-253 (2010)
Svensson, S.L., et al. J. Biol. Chem. 285(21): 16105-16115 (2010)
M'Bika, J.P., et al. J. Gen. Virol. 91 (PT 5): 1346-1353 (2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Pleiotrophin / PTN antibody

Pleiotrophin / PTN Rabbit Aff - Purified Hu E, P, WB
50 µg / €370.00
  Acris Antibodies GmbH

Pleiotrophin / PTN antibody

  Goat Anti-Pleiotrophin / PTN Antibody  
(0.3ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Pleiotrophin / PTN antibody

  Anti-PTN Rabbit Polyclonal Antibody  
Predicted band size: 19 kDa . Positive control: Human colon cancer tissue lysate. Recommended dilution: 1/500-2000. (Gel: 12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Pleiotrophin / PTN (C-term) antibody

Immunohistochemistry analysis in human brain tissue (Formalin-fixed, Paraffin-embedded) using Pleiotrophin / PTN antibody Cat.-No. AP53507PU-N (C-term), followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of Pleiotrophin antibody for IHC. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Ptn - mouse gene knockout kit via CRISPR

Ptn - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ptn - mouse gene knockout kit via CRISPR

Ptn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptn - mouse gene knockout kit via CRISPR

Ptn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptn - mouse gene knockout kit via CRISPR

Ptn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Pleiotrophin / PTN

  Purified recombinant protein of Human pleiotrophin (PTN).  
Pleiotrophin / PTN Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli

Regular Price: 20 µg / €199.00

Special Price: 20 µg / €139.00

  OriGene Technologies, Inc.

Pleiotrophin / PTN (full length)

  Purified recombinant protein of Human pleiotrophin (PTN), full length, Tag free, expressed in E. coli, 100ug  
Pleiotrophin / PTN Human > 95 %
Preparation: .
Purity Detail: > 95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
0.1 mg / €399.00
  OriGene Technologies, Inc.

Pleiotrophin / PTN

12% SDS-PAGE separation of Human OSF-1 
1. M.W. marker - 14, 21, 31, 45, 66, 97 kDa 
2. reduced and heated sample, 10µg/lane 
3. non-reduced and non-heated sample, 10µg/lane Human Purified > 95 % pure by SDS PAGE E. coli
0.1 mg / €470.00
  Acris Antibodies GmbH

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ptn (GFP-tagged ORF) - Rat pleiotrophin (Ptn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ptn (GFP-tagged ORF) - Rat pleiotrophin (Ptn), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ptn (Myc-DDK-tagged ORF) - Rat pleiotrophin (Ptn), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ptn (Myc-DDK-tagged ORF) - Rat pleiotrophin (Ptn), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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