PLK4 / SAK / STK18 antibody

Principal name

PLK4 / SAK / STK18 antibody

Alternative names for PLK4 / SAK / STK18 antibody

Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase Sak, Serine/threonine-protein kinase 18

SwissProt ID

O00444 (Human), Q64702 (Mouse)

Gene ID

10733 (PLK4)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of PLK4 / SAK / STK18 antibody

Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.

General readings

Syed N et al. Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies. Blood. 2006 Jan 1;107(1):250-6. Epub 2005 Sep 13.
PMID: 16160013

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLK4 / SAK / STK18 (N-term) antibody

TA302688 (0.1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu WB
20 µg / €200.00
  Acris Antibodies GmbH

PLK4 / SAK / STK18 (N-term) antibody

TA302688 (0.1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PLK4 / SAK / STK18 antibody

PLK4 / SAK / STK18 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PLK4 / SAK / STK18 antibody

Immunoprecipitation of PLK4 transfected lysate using anti-PLK4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with PLK4 MaxPab mouse polyclonal antibody (B01) (H00010733-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

PLK4 / SAK / STK18 antibody

PLK4 monoclonal antibody (M01), clone 1C8 Western Blot analysis of PLK4 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 1C8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PLK4 / SAK / STK18 antibody

Western Blot: PLK4 Antibody [NB100-894] - NB100-894 (2ug/ml) staining of Human Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PLK4 / SAK / STK18 antibody

PLK4 / SAK / STK18 Rabbit IgG Hu ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

PLK4 / SAK / STK18 antibody

Immunohistochemistry-Paraffin: PLK4 Antibody [NBP1-87095] Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PLK4 / SAK / STK18

PLK4 / SAK / STK18 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PLK4 / SAK / STK18

PLK4 / SAK / STK18 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

PLK4 / SAK / STK18

PLK4 / SAK / STK18 Human
0.1 mg / €1,260.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

PLK4 (Human) IP-WB Antibody Pair

PLK4 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PLK4 293T Cell Transient Overexpression Lysate(Denatured)

PLK4 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

PLK4 overexpression lysate

PLK4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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