PLKK1 antibody

Principal name

PLKK1 antibody

Alternative names for PLKK1 antibody

Polo-like kinase kinase 1, xPlkk1, stk10

SwissProt ID

Q9YHC9 (Xenla)

Gene ID

373731 (stk10-a)

Available reactivities

Frog, Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Ze (Zebrafish)

Available hosts


Available applications

Western blot / Immunoblot (WB)

Background of PLKK1 antibody

Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.

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