PLVAP antibody

Principal name

PLVAP antibody

Alternative names for PLVAP antibody

Plasmalemma vesicle protein 1, PV1, PV-1, MECA-32 antigen, FELS, Endothelial cell marker, Endothelial cell surface marker, Endothelial Cell Antigen, Plasmalemma vesicle-associated protein, Fenestrated endothelial-linked structure protein

SwissProt ID

Q91VC4 (Mouse), Q9BX97 (Human), Q9WV78 (Rat)

Gene ID

83483 (PLVAP), 84094 (Plvap), 56765

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PLVAP antibody

PLVAP is a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumour angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

General readings

Keuschnigg, J., et al. Blood 114(2):478-484(2009)
Carson-Walter, E.B., et al. Clin. Cancer Res. 11(21):7643-7650(2005)
Strickland, L.A., et al. J. Pathol. 206(4):466-475(2005)
Stan, R.V., et al. Mol. Biol. Cell 15(8):3615-3630(2004)
Hnasko, R., et al. J. Endocrinol. 175(3):649-661(2002)
Stan, R.V., et al. Genomics 72(3):304-313(2001)
Stan, R.V., et al. J. Cell Biol. 145(6):1189-1198(1999)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PLVAP antibody

  Rat Monoclonal anti-Panendothelial Cell antigen Antibody  
bEND.3 cells stained with MECA-32 Alexa Fluorreg; 488 Rat MECA-32 Purified Ms F, ICC/IF, IP, P, WB
50 µg / €248.00
  OriGene Technologies, Inc.

PLVAP antibody

PLVAP Rat IgG2a MECA-32 Biotin Ms C, F
0.1 mg / €250.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Rat IgG2a MECA-32 FITC Ms F
0.1 mg / €280.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Rat IgG2a MECA-32 Purified Ms C, F
0.25 mg / €400.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Rat IgG2a MECA-32 Purified Ms C, F
0.1 mg / €240.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Rat IgG2a MECA-32 Purified Ms C, F
25 µg / €170.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Mouse IgG1 174/2 FITC Hu C, ICC/IF, WB
0.1 mg / €580.00
  Acris Antibodies GmbH

PLVAP antibody

PLVAP Mouse IgG1 174/2 Purified Hu C, ICC/IF, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

PLVAP (Center) antibody

Western blot analysis of PLVAP Antibody (Center) Cat.-No AP53357PU-N in HL-60 cell line lysates (35ug/lane). PLVAP (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PLVAP - human gene knockout kit via CRISPR

PLVAP - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PLVAP - human gene knockout kit via CRISPR

PLVAP - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLVAP - human gene knockout kit via CRISPR

PLVAP - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PLVAP - human gene knockout kit via CRISPR

PLVAP - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Plvap - mouse gene knockout kit via CRISPR

Plvap - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PLVAP

  Recombinant protein of human plasmalemma vesicle associated protein (PLVAP)  
PLVAP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PLVAP overexpression lysate

PLVAP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PLVAP (mGFP-tagged)-Human plasmalemma vesicle associated protein (PLVAP), 200 uL, >10^7 TU/mL

Lenti ORF particles, PLVAP (mGFP-tagged)-Human plasmalemma vesicle associated protein (PLVAP), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PLVAP (Myc-DDK-tagged)-Human plasmalemma vesicle associated protein (PLVAP), 200 uL, >10^7 TU/mL

Lenti ORF particles, PLVAP (Myc-DDK-tagged)-Human plasmalemma vesicle associated protein (PLVAP), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Plvap (GFP-tagged) - Mouse plasmalemma vesicle associated protein (Plvap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Plvap (GFP-tagged) - Mouse plasmalemma vesicle associated protein (Plvap), 200 uL, >10^7 TU/mL  
200 µl / €1,040.00
  OriGene Technologies, Inc.

Lenti ORF particles, Plvap (Myc-DDK-tagged) - Mouse plasmalemma vesicle associated protein (Plvap), 200 uL, >10^7 TU/mL

Lenti ORF particles, Plvap (Myc-DDK-tagged) - Mouse plasmalemma vesicle associated protein (Plvap), 200 uL, >10^7 TU/mL  
200 µl / €930.00
  OriGene Technologies, Inc.

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