PMS1 antibody

Principal name

PMS1 antibody

Alternative names for PMS1 antibody

PMSL1, PMS1 protein homolog 1, DNA mismatch repair protein PMS1

SwissProt ID

P14242 (Yeast), P54277 (Human), P54280 (Schpo)

Gene ID

5378 (PMS1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of PMS1 antibody

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

General readings

Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)
Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Adeyemo, A., et al. PLoS Genet. 5 (7), E1000564 (2009)

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PMS1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using PMS1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PMS1 antibody

Predicted band size: 106 kDa . Positive control: HeLa, Jurkat, Molt-4 and HepG2 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: HeLa cell lysate Lane2: Jurkat cell lysate Lane3: Molt-4 cell lysate Lane4: HepG2 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Rb WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PMS1 antibody

Western blot analysis of extracts of various cell lines, using PMS1 antibody. Rabbit IgG Purified Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PMS1 (C-term) antibody

Western blot analysis of PMS1 Antibody (C-term) Cat.-No AP53363PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PMS1 antibody detected the PMS1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PMS1 antibody

PMS1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PMS1 antibody

Detection limit for recombinant GST tagged PMS1 is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 2G10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PMS1 antibody

PMS1 Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

PMS1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using PMS1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

PMS1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using PMS1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

PMS1 antibody

Immunohistochemical analysis of PMS1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PMS1 antibody

Immunohistochemical analysis of PMS1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PMS1 antibody

Immunohistochemical analysis of PMS1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PMS1 antibody

PMS1 Rabbit IgG Aff - Purified Hu E, P
0.1 mg / €360.00
  Novus Biologicals Inc.

PMS1 antibody

PMS1 Rabbit IgG Aff - Purified Hu E, P
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PMS1

PMS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PMS1

PMS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

PMS1

PMS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PMS1

PMS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PMS1 overexpression lysate

PMS1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

19 Item(s)

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