PNPO antibody

Principal name

PNPO antibody

Alternative names for PNPO antibody

Pyridoxine-5'-phosphate oxidase, Pyridoxamine-phosphate oxidase

SwissProt ID

O88794 (Rat), Q5E9K3 (Bovin), Q91XF0 (Mouse), Q9NVS9 (Human)

Gene ID

55163 (PNPO)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of PNPO antibody

NR1F1; Retinoid related orphan receptor alpha (ROR alpha) is a NR1 Thyroid Hormone Like Receptor. ROR alpha has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. These isotypes have been shown to differ in only their amino terminus, and their spatiotemporal expression appears to be under isoform specific regulation. ROR alpha isoforms have the same DNA binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The structure of the ligand binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated. ROR alpha expression has been documented in human adipose, brain, breast, heart, liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. Research has shown that these proteins are key factors in the regulation of many physiological processes such as cell growth and differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, and migratory capacities of cancer cells.

General readings

Musayev, F.N., et al. J. Biol. Chem. 284(45):30949-30956(2009)
Khayat, M., et al. Mol. Genet. Metab. 94(4):431-434(2008)
Song, H., et al. Schizophr. Res. 97 (1-3), 264-270 (2007)
Mills, P.B., et al. Hum. Mol. Genet. 14(8):1077-1086(2005)
Kang, J.H., et al. Eur. J. Biochem. 271(12):2452-2461(2004)
Musayev, F.N., et al. Protein Sci. 12(7):1455-1463(2003)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PNPO antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PNPO mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503356) Mouse IgG2b OTI1H9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PNPO antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PNPO mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503506) Mouse IgG2a OTI1G9 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PNPO antibody

WB Suggested Anti-PNPO Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PNPO antibody

Anti-PNPO mouse monoclonal antibody (TA503178) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PNPO(RC200133). Mouse IgG1 OTI2F8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PNPO antibody

Anti-PNPO mouse monoclonal antibody (TA503249) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PNPO(RC200133). Mouse IgG2a OTI3B3 Purified Can, Hu, Mky, Rt ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PNPO antibody

The extracts of HepG2(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PNPO (1:500 ~ 1:5000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT2C7 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

PNPO antibody

The extracts of HepG2(40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PNPO (1:500 ~ 1:5000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG1 AT2C7 Purified Hu E, WB
50 µl / €230.00
  Acris Antibodies GmbH

PNPO (C-term) antibody

Western blot analysis of PNPO Antibody (C-term) Cat.-No AP53372PU-N in 293 cell line lysates (35ug/lane). PNPO (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PNPO antibody

PNPO polyclonal antibody (A01), Lot # 060529JCS1 Western Blot analysis of PNPO expression in MES-SA/Dx5 ( Cat # L021V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PNPO antibody

Western Blot analysis of PNPO expression in transfected 293T cell line (H00055163-T01) by PNPO MaxPab polyclonal antibody.

Lane 1: PNPO transfected lysate(28.71 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PNPO antibody

PNPO Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PNPO antibody

PNPO Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PNPO antibody

Human Muscle; WB Suggested Anti-PNPO Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Muscle; PNPO antibody - N-terminal region (ARP58515_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PNPO

PNPO Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PNPO (57-261, His-tag)

PNPO Human Purified > 90 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

PNPO (57-261, His-tag)

PNPO Human Purified > 90 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

PNPO

PNPO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PNPO

PNPO Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PNPO

PNPO Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PNPO

PNPO Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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