Podocalyxin / PODXL antibody

Principal name

Podocalyxin / PODXL antibody

Alternative names for Podocalyxin / PODXL antibody

Podocalyxin-like protein 1, PCLP, PCLP1, PCLP-1, GCTM-2 antigen, Hematopoietic Stem Cell Marker

SwissProt ID

O00592 (Human), Q28645 (Rabit), Q9R0M4 (Mouse), Q9WTQ2 (Rat)

Gene ID

5420 (PODXL), 192181 (Podxl), 27205

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Can (Canine)

Available hosts

Goat, Rabbit, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Immunofluorescence (IF)

Background of Podocalyxin / PODXL antibody

Podocalyxin, also known as podocalyxin-like or PDXL, is a member of the CD34 transmembrane sialomucin family. Like other sialoglycoproteins, podocalyxin plays important roles in mediating cellular migration and cell-cell adhesion. Podocalyxin was first discovered in podocytes, the terminally differentiated epithelial cells lining the kidney glomeruli. Podocalyxin is expressed at high levels on the podocyte foot projections and plays essential roles in kidney development and homeostasis, particularly blood filtration and urine formation.
Podocalyxin is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons (reviewed in Nielsen, 2009). Aberrant expression of podocalyxin has been described in a variety of cancers including breast, prostate, liver, pancreatic, kidney and leukemia. Human podocalyxin migrates as a 165/170 kDa doublet on SDS-PAGE; however there are many post-translational modifications which may impact its actual size (Kershaw, 1997).
Antibody to podocalyxin has been reported to be a useful biomarker for various pathological conditions. For example, podocalyxin antibody can identify podocytes in the urine, also known as podocyturia, which can be indicative of glomerular disease, pre-eclampsia, and other kidney pathology (reviewed in Chen, 2012). Additionally, podocalyxin antibody studies have indicated that highly podocalyxin-positive tumors or podocalyxin dysregulation in general can be potentially linked to more aggressive tumors and poorer outcomes (Nielson, 2009). Hence, podocalyxin antibody may be used as part of a biomarker antibody panel to study expression of proteins associated with tumorigenesis.

General readings

Vitureira N., et al. (2010) PLoS ONE 8:e12003.Nielsen JS., et al. (2007) PLoS ONE 2:E237.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Podocalyxin / PODXL antibody

  PODXL mouse monoclonal antibody, clone OTI8D6  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PODXL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807749)(1:150) Mouse IgG1 OTI8D6 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Podocalyxin / PODXL antibody

  PODXL mouse monoclonal antibody, clone OTI2C6 (formerly 2C6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PODXL mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807750)(1:150) Mouse IgG1 OTI2C6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Podocalyxin / PODXL antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and kidney tissues (right) using PODXL mouse mAb with DAB staining. Mouse IgG1 5F5 Ascites Hu E, F, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Formalin-Fixed, Paraffin-Embedded Human angiosarcoma stained with Podocalyxin Antibody Cat.-No AM32857PU (Clone 3D3). Mouse IgG1 3D3 Purified Hu, Rb, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Formalin-Fixed, Paraffin-Embedded Human angiosarcoma stained with Podocalyxin Antibody Cat.-No AM32857PU (Clone 3D3). Mouse IgG1 3D3 Purified Hu, Rb, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Formalin-Fixed, Paraffin-Embedded Human angiosarcoma stained with Podocalyxin Antibody Cat.-No AM32857PU (Clone 3D3). Mouse IgG1 3D3 Purified Hu, Rb, Rt C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

  Mouse Monoclonal Antibody against TRA-1-60 (TRA-1-60(R)) -Neuraminidase resistant -Embryonic Stem Cell Marker  
Western blot analysis in NTERA-2 cl.D1 whole cell lysate Mouse IgM TRA-1-60(R) Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Mouse Monoclonal Antibody against TRA-1-81 (TRA-1-81) - Embryonic Stem Cell Marker  
Western blot analysis of expression in NTERA-2 cl.D1 whole cell lysate. Mouse IgM TRA-1-81 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Goat Polyclonal Antibody against PODXL  
TA302578 (0.5µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Rabbit Polyclonal Podocalyxin Antibody  
Western Blot: PODXL Antibody - Detection of podocalyxin in human lung lysate Rabbit Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Anti-PODXL Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PODXL antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Anti-PODXL Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human brain and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using PODXL antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Rabbit Polyclonal Anti-PODXL Antibody  
WB Suggested Anti-PODXL Antibody Titration: 5.0 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  Rabbit Polyclonal Anti-PODXL Antibody  
WB Suggested Anti-PODXL Antibody Titration: 0.5 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Podocalyxin / PODXL antibody

  PODXL mouse monoclonal antibody, clone OTI9C2 (formerly 9C2)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PODXL mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807762)(1:150) Mouse IgG1 OTI9C2 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Podocalyxin / PODXL antibody

Western blot analysis using PODXL mAb against human PODXL (AA: 109-324) recombinant protein. (Expected MW is 47.3 kDa) Mouse IgG1 5D4 Ascites Hu E, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Flow cytometric analysis of mouse Podocalyxin/PCLP1 expression on LO cells. Dotted line indicates the reaction of isotypic control to the cells. Solid line indicates the reaction of AM26444AF-N to the cells. Rat IgG1 10B9 Azide Free Ms F
0.1 ml / €390.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Flow cytometric analysis of mouse Podocalyxin/PCLP1 expression on LO cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26444BT-N to the cells. Rat IgG1 10B9 Biotin Ms F
1 ml / €400.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Flow cytometric analysis of Mouse Podocalyxin/PCLP1 expression on LO cells. Open histogram indicates the reaction of Isotypic control to the cells. Shaded histogram indicates the reaction of AM26444FC-N to the cells. Rat IgG1 10B9 FITC Ms F
1 ml / €390.00
  Acris Antibodies GmbH

Podocalyxin / PODXL antibody

Flow cytometric analysis of mouse PCLP1 expression on WR19L (left) and LO (right). Open histogram indicates the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26444RP-N to the cells. Rat IgG1 10B9 PE Ms F
50 Tests / €400.00
  Acris Antibodies GmbH

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