POLG1 antibody

Principal name

POLG1 antibody

Alternative names for POLG1 antibody

POLG, MDP1, POLGA, DNA polymerase subunit gamma-1, PolG-alpha, Mitochondrial DNA polymerase catalytic subunit

SwissProt ID

P54098 (Human), P54099 (Mouse), Q91684 (Xenla), Q92076 (Chick), Q9QYV8 (Rat)

Gene ID

5428 (POLG), 85472 (Polg)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of POLG1 antibody

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic / apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic / apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

General readings

Tong, Z.B., et al. Fertil. Steril. 94(7):2932-2934(2010).
Stewart, J.D., et al. Hepatology 52(5):1791-1796(2010).
Batabyal, D., et al. J. Biol. Chem. 285(44):34191-34201(2010).
Wang, W., et al. Nucleic Acids Res. (2010) In press.
Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

POLG1 antibody

  Rabbit Polyclonal antibody to DNA polymerase gamma (polymerase (DNA directed), gamma)  
Sample (30 ug of whole cell lysate). A: MCF-7. 5% SDS PAGE. TA308753 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

POLG1 (C-term) antibody

  Rabbit polyclonal POLG Antibody (C-term)  
POLG Antibody (C-term) (Cat. #TA324581) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). Rabbit Ig Aff - Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

POLG1 (829-1201) antibody

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

POLG - human gene knockout kit via CRISPR

POLG - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

POLG - human gene knockout kit via CRISPR

POLG - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

POLG - human gene knockout kit via CRISPR

POLG - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

POLG - human gene knockout kit via CRISPR

POLG - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, POLG (mGFP-tagged) - Human polymerase (DNA directed), gamma (POLG), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, POLG (mGFP-tagged) - Human polymerase (DNA directed), gamma (POLG), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, POLG (mGFP-tagged)-Human polymerase (DNA directed), gamma (POLG), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, POLG (mGFP-tagged)-Human polymerase (DNA directed), gamma (POLG), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, POLG (Myc-DDK tagged) - Human polymerase (DNA directed), gamma (POLG), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, POLG (Myc-DDK tagged) - Human polymerase (DNA directed), gamma (POLG), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, POLG (Myc-DDK-tagged)-Human polymerase (DNA directed), gamma (POLG), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, POLG (Myc-DDK-tagged)-Human polymerase (DNA directed), gamma (POLG), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

11 Item(s)

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