POLG1 antibody

Principal name

POLG1 antibody

Alternative names for POLG1 antibody

POLG, MDP1, POLGA, DNA polymerase subunit gamma-1, PolG-alpha, Mitochondrial DNA polymerase catalytic subunit

SwissProt ID

P54098 (Human), P54099 (Mouse), Q91684 (Xenla), Q92076 (Chick), Q9QYV8 (Rat)

Gene ID

5428 (POLG), 85472 (Polg)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of POLG1 antibody

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic / apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic / apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

General readings

Tong, Z.B., et al. Fertil. Steril. 94(7):2932-2934(2010).
Stewart, J.D., et al. Hepatology 52(5):1791-1796(2010).
Batabyal, D., et al. J. Biol. Chem. 285(44):34191-34201(2010).
Wang, W., et al. Nucleic Acids Res. (2010) In press.
Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

POLG1 antibody

Sample (30 ug of whole cell lysate). A: MCF-7. 5% SDS PAGE. TA308753 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

POLG1 (C-term) antibody

POLG Antibody (C-term) (Cat. #TA324581) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). Rabbit Ig Aff - Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

POLG1 (829-1201) antibody

Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

POLG1 (N-term) antibody

Rat Lung; WB Suggested Anti-Polg Antibody. . Titration: 1.0 ug/ml. . Positive Control: Rat Lung; Polg antibody - N-terminal region (ARP48580_P050) in Rat Lung cells using Western Blot Rabbit Aff - Purified Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

POLG1 antibody

Western  Blot:  DNA Polymerase gamma Antibody [NBP1-33633] – Western blot analysis of DNA Polymerase gamma on MCF-7 lysates using NBP1-33633 at a dilution of 1:1000. 30ug whole cell lysate loaded on 5% SDS PAGE gel. Rabbit IgG Hu, Rt ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

POLG1 antibody

POLG1 Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µl / €480.00
  Novus Biologicals Inc.

POLG1 antibody

POLG1 Rabbit Aff - Purified Hu, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

POLG1

POLG1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

POLG1

POLG1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

9 Item(s)

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