POLR3C / RPC3 antibody

Principal name

POLR3C / RPC3 antibody

Alternative names for POLR3C / RPC3 antibody

RPC62, DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3, RNA polymerase III 62 kDa subunit

SwissProt ID

P32349 (Yeast), Q2TBL4 (Bovin), Q5XIL3 (Rat), Q7ZUX1 (Danre), Q9BUI4 (Human), Q9C106 (Schpo), Q9D483 (Mouse)

Gene ID

10623 (POLR3C), 74414 (Polr3c), 310685

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Rb (Rabbit), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P)

Background of POLR3C / RPC3 antibody

D-dependent R polymerase catalyzes the transcription of D into R using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of R polymerase III which synthesizes small Rs, such as 5S rR and tRs. POLR3C may direct with other members of the subcomplex R Pol III binding to the TFIIIB-D complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within R polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and D viruses.POLR3C acts as nuclear and cytosolic D sensor involved in inte immune response. POLR3C can sense non-self dsD that serves as template for transcription into dsR. The non-self R polymerase III transcripts, such as Epstein-Barr virus-encoded Rs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

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