Polyubiquitin-C / UBC antibody

Principal name

Polyubiquitin-C / UBC antibody

Gene ID

7316

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Polyubiquitin-C / UBC antibody

Ubiquitin is a highly conserved protein, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin .Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Polyubiquitin-C / UBC (C-term) antibody

Anti-UBC / Ubiquitin C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit IgG Purified Hu ICC/IF, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC (C-term) antibody

Immunohistochemistry: AP11230PU-N Ubiquitin antibody staining of Formalin-Fixed, Paraffin-Embedded Human cancer tissue, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu ICC/IF, P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

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