Polyubiquitin-C / UBC antibody

Principal name

Polyubiquitin-C / UBC antibody

Gene ID

7316 (UBC), 50522

Available reactivities

Hu (Human), Mam (Mammalia)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunoelectron Microscopy (EM)

Background of Polyubiquitin-C / UBC antibody

Ubiquitin is a small (8.5 kD) regulatory protein that is ubiquitously expressed in tissues of eukaryotic organisms. There are four genes in the human genome that produce ubiquitin; UBB, UBC, UBA52 and RPS27A. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. The UBB and UBC genes code for polyubiquitin precursor proteins. Ubiquitination is a post-translational modification where a ubiquitin subunit is attached to a protein. Addition of ubiquitin can signal for degradation via the proteasome, alter cellular location, promote or prevent protein interactions, or affect activity. Ubiquitination is carried out stepwise by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The cascade results in ubiquitin bound to lysine residues on the protein or to the amino group of the protein's N-terminus. Ubiquitinations can be either a single ubiquitin unit (monoubiquitination) or a chain of ubiquitin (polyubiquitination). Only poly-ubiquitination on defined lysines, mostly on K48 and K29, is related to degradation with the proteasome, while other polyubiquitinations (e.g. on K63, K11, K6) and monoubiquitinations may regulate processes such as endocytic trafficking, inflammation, translation and DNA repair. A frameshift mutation in ubiquitin B can result in a truncated peptide missing the C-terminal glycine. This abnormal peptide, known as UBB+1, has been shown to accumulate selectively in Alzheimer's disease and other tauopathies.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Polyubiquitin-C / UBC (C-term) antibody

  UBC / Ubiquitin C Rabbit Polyclonal (C-Terminus) Antibody  
Anti-UBC / Ubiquitin C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit IgG Purified Hu ICC/IF, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC antibody

  Mouse Monoclonal anti-Ubiquitin, 64-76 (free/bound) Antibody  
Anti Ubiquitin (Clone 5-25) probed against Lane 1: Molecular weight ladder. Labe 2: 6-His Ubiquitin Lane 3: HeLa cell lysate. Mouse 5-25 Purified Mam E, EM, P, WB
200 µl / €879.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC antibody

  Mouse Monoclonal anti-Ubiquitin, 50-65 (bound) Antibody  
Polyubiquitin-C / UBC Mouse 3-39 Purified Mam E, IP, P, WB
200 µl / €879.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC antibody

  Mouse Monoclonal anti-Ubiquitin Antibody  
Western Blot showing specificity of Ubiquitin (Clone P4G7) 1/1000.  Lane 1: Molecular weight marker. Lane 2: 6-his ubiquitin protein. Mouse IgG1 P4G7 Purified Hu E, WB
200 µl / €325.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC antibody

  Mouse Monoclonal anti-Ubiquitin Antibody  
Mouse recombinant ubiquitin was resolved by electrophoresis, transferred to nitrocellulose and probed with anti-Ubiquitin antibody, clone P4D1. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse P4D1 Purified IP, P, WB
25 µg / €248.00
  OriGene Technologies, Inc.

Polyubiquitin-C / UBC (C-term) antibody

Immunohistochemistry: AP11230PU-N Ubiquitin antibody staining of Formalin-Fixed, Paraffin-Embedded Human cancer tissue, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

UBC - human gene knockout kit via CRISPR

UBC - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

UBC - human gene knockout kit via CRISPR

UBC - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBC - human gene knockout kit via CRISPR

UBC - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

UBC - human gene knockout kit via CRISPR

UBC - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, UBC (mGFP-tagged)-Human ubiquitin C (UBC), 200 uL, >10^7 TU/mL

Lenti ORF particles, UBC (mGFP-tagged)-Human ubiquitin C (UBC), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, UBC (Myc-DDK-tagged)-Human ubiquitin C (UBC), 200 uL, >10^7 TU/mL

Lenti ORF particles, UBC (Myc-DDK-tagged)-Human ubiquitin C (UBC), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ubc (GFP-tagged ORF) - Rat ubiquitin C (Ubc), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ubc (GFP-tagged ORF) - Rat ubiquitin C (Ubc), 200 uL, >10^7 TU/mL  
200 µl / €1,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ubc (Myc-DDK-tagged ORF) - Rat ubiquitin C (Ubc), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ubc (Myc-DDK-tagged ORF) - Rat ubiquitin C (Ubc), 200 uL, >10^7 TU/mL  
200 µl / €1,373.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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