POMC antibody

Principal name

POMC antibody

Alternative names for POMC antibody

Pro-opiomelanocortin, Corticotropin-Lipotropin

SwissProt ID

P01189 (Human), P01190 (Bovin), P01191 (Sheep), P01192 (Pig), P01193 (Mouse), P01194 (Rat), P06297 (Rabit)

Gene ID

5443 (POMC), 18976 (Pomc)

Available reactivities

Rt (Rat), Hu (Human), Broad, Bov (Bovine), Can (Canine), Frog, Mky (Monkey), Ms (Mouse), Sh (Sheep), Bear, Por (Porcine), Camel, Mam (Mammalia), GP (Guinea Pig), Br

Available hosts

Rabbit, Mouse, Goat, Chicken

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Dot blot (Dot), Flow Cytometry (F)

Background of POMC antibody

The pro-opiomelanocortin (POMC) is the precursor of many pituitary hormones including Adenocorticotrphin (ACTH). The POMC was first identified in the anterior intermediate lobe of pituitary but is expressed in many other tissues including CNS, skin, and placenta. Following synthesis POMC undergoes extensive post-translational modifications and proteolysis producing not only ACTH but also a number of other biological active peptides. The proteolysis and post-translational modification are dependent upon tissue thus producing a different combination of peptides from the same precursor protein. These biological active peptides have diverse range of function ranging from pigmentation to adrenal and regulation of feeding behavior (1). ACTH is produced in the anterior intermediate lobe of the pituitary and in neurons in the brain. ACTH regulate the corticosteroid/glucocorticoid production in the adrenal cortex. Other hormones that are produced by POMC gene are beta endorphins, met enkaphalin (endogenous opiods), melanocyte stimulating hormone that increase the pigmentation of skin by increasing the production of melanin in melanocytes. Other hormone s are corticotrophin like intermediate lobe peptide (CLIP), Lipotrophins and endorphins. Defects in the POMC gene have been known to cause several defects including obesity. Ectopic immunodeficiency has been found in many tumors including prostate carcinoma, thymoma, pancreatic tumors. The testicular adrenal rest tumors are frequently associated with hyper adrenal hyperplasia, and ACTH-dependent tumors can be easily detected from leydig-cell tumors by ACTH staining (2). The serum lelves of ACTH are stimulated by adrenal-hypathamic-pituitary axis, ACTH levels are also positively correlated with stress levels.

General readings

Muhlhausler BS, Adam CL, Marrocco E, Findlay PA, Roberts CT, McFarlane JR, Kauter KG, McMillen IC. Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. J Physiol. 2005 Jan 20; [Epub ahead of print]

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Adrenocorticotropic Hormone (ACTH) antibody

AM11087PU ACTH antibody staining of Human Pituitary. Mouse IgG1 SPM501 Purified Hu P
0.5 ml / €370.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) antibody

AM11087PU ACTH antibody staining of Human Pituitary. Mouse IgG1 SPM501 Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) antibody

AM11087PU ACTH antibody staining of Human Pituitary. Mouse IgG1 SPM501 Purified Hu P
0.1 ml / €200.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-fixed, Paraffin-Embedded Human pituitary gland stained with ACTH Antibody Cat.-No AM32828PU (Clone AH26) at 1/2000 using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining. Mouse IgG1 AH26 Purified Br, Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-fixed, Paraffin-Embedded Human pituitary gland stained with ACTH Antibody Cat.-No AM32828PU (Clone AH26) at 1/2000 using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining. Mouse IgG1 AH26 Purified Br, Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-fixed, Paraffin-Embedded Human pituitary gland stained with ACTH Antibody Cat.-No AM32828PU (Clone AH26) at 1/2000 using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining. Mouse IgG1 AH26 Purified Br, Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (N-term) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 57 Purified Hu, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (N-term) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 57 Purified Hu, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (N-term) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 57 Purified Hu, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-paraffin human pituitary gland stained with ACTH Antibody Cat.-No AM50155PU (Clone SPM333). Mouse IgG1 SPM333 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-paraffin human pituitary gland stained with ACTH Antibody Cat.-No AM50155PU (Clone SPM333). Mouse IgG1 SPM333 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Formalin-paraffin human pituitary gland stained with ACTH Antibody Cat.-No AM50155PU (Clone SPM333). Mouse IgG1 SPM333 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 2F6 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 2F6 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (1-24) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 2F6 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 AH26 + 57 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 AH26 + 57 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) antibody

Adrenocorticotropic Hormone (ACTH) Mouse IgG1 AH26 + 57 Purified Hu, Ms, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (N-term) antibody

Human pituitary stained with
Anti-ACTH antibody. Rabbit Purified Can, Hu P, WB
0.5 ml / €300.00
  Acris Antibodies GmbH

Adrenocorticotropic Hormone (ACTH) (N-term) antibody

Human pituitary stained with
Anti-ACTH antibody. Rabbit Purified Hu P, WB
1 ml / €410.00
  Acris Antibodies GmbH

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