PPAP2B / LPP3 antibody

Principal name

PPAP2B / LPP3 antibody

Alternative names for PPAP2B / LPP3 antibody

PAP2-beta, PAP2B, VCIP, Lipid phosphate phosphohydrolase 3, Phosphatidic acid phosphatase 2b, Phosphatidate phosphohydrolase type 2b, Vascular endothelial growth factor and type I collagen-inducible protein

SwissProt ID

O14495 (Human), P97544 (Rat), Q3SZE3 (Bovin), Q99JY8 (Mouse)

Gene ID

8613 (PPAP2B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PPAP2B / LPP3 antibody

Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently,multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8].
Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PPAP2B / LPP3 antibody

Western blot analysis using LPP3 antibody on bacterially expressed LPP3 protein when untreated (-) and treated with with 0.1 mM IPTG (isopropyl-beta-D-thiogal actopyranoside) (+) at a dilution of 10 µg/ml. Rabbit IgG Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

PPAP2B / LPP3 antibody

Western blot analysis using PAP2B antibody on human brain lysate. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
10 Blots / €480.00
  Acris Antibodies GmbH

PPAP2B / LPP3 antibody

Figure 1. Staining PPAP2B in Placenta by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PPAP2B / LPP3 antibody

PPAP2B / LPP3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PPAP2B / LPP3 antibody

Western blot analysis using PPAP2B polyclonal antibody ( Cat # PAB10123 ) on bacterially expressed PPAP2B protein when untreated (-) and treated with with 0.1 mM IPTG (isopropyl-beta-D-thiogalactopyranoside) (+) at a dilution of 10 µg/ml. Hu
0.1 mg / €400.00
  Abnova Taiwan Corp.

PPAP2B / LPP3 antibody

PPAP2B / LPP3 Rabbit Hu P, WB
50 µg / €480.00
  Novus Biologicals Inc.

PPAP2B / LPP3 antibody

Immunohistochemistry-Paraffin: PPAP2B Antibody [NBP1-82825] - Immunohistochemical staining of human duodenum shows strong membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PPAP2B / LPP3 (transcript variant 1)

PPAP2B / LPP3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PPAP2B / LPP3

PPAP2B / LPP3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PPAP2B / LPP3

PPAP2B / LPP3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PPAP2B overexpression lysate

PPAP2B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

per page
  • LinkedIn