PPAP2C / LPP2 antibody

Principal name

PPAP2C / LPP2 antibody

Alternative names for PPAP2C / LPP2 antibody

PAP2-gamma, Lipid phosphate phosphohydrolase 2, Phosphatidic acid phosphatase 2c, Phosphatidate phosphohydrolase type 2c

SwissProt ID

O43688 (Human), Q2HJ61 (Bovin), Q8K593 (Rat), Q9DAX2 (Mouse)

Gene ID

8612 (PPAP2C)

Available reactivities

Hu (Human), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of PPAP2C / LPP2 antibody

Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG) [1]. Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3 [6]. S1P [7] and LPA [8] regulate the proliferation, differentiation, apoptosis and migration of cells by binding to a family of G protein-coupled receptors. Thus, EDG1/S1P1, EDG3/S1P3, EDG5/S1P2/AGR16/H218, EDG6/S1P4 and EDG8/S1P5/nrg-1 are high affinity S1P receptors [7] whereas EDG2/LPA1, EDG4/LPA2 and EDG7/LPA3 have high affinity for LPA [8]. Recently, the over-expression of LPP1 was shown to limit LPA-stimulated signalling in Rat2 fibroblasts [9] and LPA-stimulated DNA synthesis in HEK 293 cells [10]. Similarly, over-expression of LPP1, LPP1a and LPP2 attenuate S1P-signalling to the p42/p44 mitogen activated protein kinase cascade [11].

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PPAP2C / LPP2 antibody

Predicted band size: 33 kDa . Positive control: Mouse trachea tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PPAP2C / LPP2 antibody

Predicted band size: 33kDa. Positive control: Mouse trachea tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PPAP2C / LPP2 antibody

Western blot analysis using LPP2 antibody on vector-controlled HEK-293 cells (V) and HEK-293 cells overexpressing LPP2 protein (2) at 1 µg/ml. Rabbit IgG Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

PPAP2C / LPP2 antibody

Western blot analysis using Pan PPAP antibody on human brain lysate. Rabbit IgG Aff - Purified Hu, Por E, WB
10 Blots / €480.00
  Acris Antibodies GmbH

PPAP2C / LPP2 (C-term) antibody

Western blot analysis of anti-PPAP2C Antibody (C-term) (Cat.#AP12449PU-N) in NCI-H460 cell line lysates (35ug/lane).PPAP2C(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PPAP2C / LPP2 antibody

Western blot analysis using PPAP2C polyclonal antibody ( Cat # PAB10122 ) on vector-controlled HEK293 cells (lane 1) and HEK293 cells overexpressing PPAP2C protein (lane 2) at 1 µg/ml. Hu
0.1 mg / €400.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PPAP2C / LPP2

PPAP2C / LPP2 Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

PPAP2C / LPP2

PPAP2C / LPP2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PPAP2C / LPP2

PPAP2C / LPP2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PPAP2C overexpression lysate

PPAP2C overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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