PPP1R13L antibody

Principal name

PPP1R13L antibody

Alternative names for PPP1R13L antibody

RelA-associated inhibitor, IASPP, NKIP1, PPP1R13BL, RAI, Inhibitor of ASPP protein, NFkB-interacting protein 1, PPP1R13B-like protein

SwissProt ID

Q5I1X5 (Mouse), Q8WUF5 (Human), Q9XVN3 (Caeel)

Gene ID

10848 (PPP1R13L), 333654 (Ppp1r13l)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Ze (Zebrafish), African clawed frog, Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of PPP1R13L antibody

ASPP proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, the third member, iASPP, functionally inactivates p53. iASPP (also called protein phosphatase 1 regulatory (inhibitor) subunit 13 like protein, Inhibitor of ASPP protein, Protein iASPP, PPP1R13B-like protein and NFkappaB-interacting protein 1) plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. iASPP blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. This protein also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. iASPP is predominantly a cytoplasmic protein (isoform 1) but can also be found in the nucleus (isoform 2). iASPP is highly expressed in heart, placenta and prostate and is weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. The N-terminal region of isoform 1 is required for cytoplasmic localization. Defects in iASPP may be a cause of certain breast cancers and the protein is overexpressed in many patients suffering from breast carcinomas and expressing a wild-type p53/TP53 protein.

General readings

Tomoda,K., (2008) Cancer Sci. 99 (3), 615-622

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PPP1R13L (780-797) antibody

  Rabbit polyclonal anti-iASSP antibody  
WB using Anti-iASPP antibody shows detection of a band at ~100 kDa (arrowhead) corresponding to isoform 1 of iASPP in MCF7 whole cell lysates. Preincubation with immunizing peptide blocks specific band staining (data not shown). Approximately 35 ug of lysate was separated by SDS-PAGE. After blocking, the membrane was probed with the primary antibody diluted to 1:1,500. The membrane was washed and reacted with a 1:10,000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L]. Rabbit IgG Aff - Purified Can, Hu, Ms E, P, WB
0.1 mg / €503.00
  OriGene Technologies, Inc.

PPP1R13L antibody

  Anti-PPP1R13L Rabbit Polyclonal Antibody  
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-2: MCF7 cells, hela cells, Primary antibody: PPP1R13L Antibody at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

PPP1R13L antibody

  Rabbit Polyclonal Anti-PPP1R13L Antibody  
WB Suggested Anti-PPP1R13L Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

PPP1R13L antibody

  Rabbit Polyclonal Anti-PPP1R13L Antibody  
WB Suggested Anti-PPP1R13L Antibody Titration: 0.2-1 ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt ICC/IF, WB
50 µg / €360.00
  OriGene Technologies, Inc.

PPP1R13L antibody

  Rabbit Polyclonal Anti-PPP1R13L Antibody  
WB Suggested Anti-PPP1R13L Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €360.00
  OriGene Technologies, Inc.

PPP1R13L antibody

PPP1R13L Rabbit IgG Purified Can, Hu, Ms E, WB
50 µg / €370.00
  OriGene Technologies GmbH

PPP1R13L antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Liver. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €380.00
  OriGene Technologies GmbH

7 Item(s)

per page
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