PPP3R1 / Calcineurin B antibody

Principal name

PPP3R1 / Calcineurin B antibody

Alternative names for PPP3R1 / Calcineurin B antibody

Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, CNA2, CNB, PP2B regulatory subunit 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1

SwissProt ID

P63098 (Human), P63099 (Bovin), P63100 (Rat), Q63810 (Mouse)

Gene ID

5534 (PPP3R1), 4325534 (Os01g0209200)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Dros (Drosophila), Ms (Mouse), Ye (Yeast), Chk (Chicken), Ze (Zebrafish), African clawed frog, Mam (Mammalia), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of PPP3R1 / Calcineurin B antibody

Calcineurin is a Ser / Thr, calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin (also referred to as protein phosphatase 2B) is composed of two subunits; calcineurin A (CnA), a 60 kDa catalytic subunit which is highly homologous to protein phosphatases 1 and 2A; and a 19 kDa regulatory subunit, calcineurin B (CnB) which, like calmodulin, contains four EF-hand calcium binding sites.

Calcineurin-mediated dephosphorylation of the nuclear factor of activated T-cells (NF-AT) is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. The immunosuppressive drugs, cyclosporin A and FK506, when bound to the immunophilins, cyclophilin and FKBP respectively, inhibit dephosphorylation and activation of NF-AT by calcineurin. This inhibition is caused by the immunosuppressant/immunophilin complex simultaneously binding to both CnA and CnB which does not inhibit the phosphatase activity of CnA, but rather blocks access of the substrate to the catalytic domain of CnA.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PPP3R1 / Calcineurin B antibody

Immunohistochemistry: AP09004PU-N PPP3R1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Tonsil at 5 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit IgG Aff - Purified Bov, Dros, Hu, Ms, Rt, Ye IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PPP3R1 / Calcineurin B antibody

WB Suggested Anti-PPP3R1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: NCI-H226 cell lysate Rabbit IgG Purified Hu, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PPP3R1 / Calcineurin B antibody

PPP3R1 MaxPab rabbit polyclonal antibody. Western Blot analysis of PPP3R1 expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PPP3R1 / Calcineurin B antibody

Immunofluorescence of monoclonal antibody to PPP3R1 on HeLa cell. [antibody concentration 25 ug/ml] Mouse Ig Mix 4E1 Purified Hu, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PPP3R1 / Calcineurin B antibody

Human NCI-H226; WB Suggested Anti-PPP3R1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: NCI-H226 cell lysate; PPP3R1 antibody - N-terminal region (ARP56124_P050) in Human NCI-H226 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PPP3R1 / Calcineurin B antibody

PPP3R1 / Calcineurin B Mouse IgG1 CC-6 Ascites Hu, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

PPP3R1 / Calcineurin B antibody

Western Blot:  Calcineurin B Antibody [NBP1-32720] - (30 ug of whole cell lysate) A: 293T B: A431 C: H1299 D: HeLa E: Hep G2  15% SDS PAGE diluted at 1:1000 Rabbit IgG Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PPP3R1 / Calcineurin B antibody

Western Blot: Calcineurin B Antibody [NBP1-56816] - This Anti-PPP3R1 antibody was used in Western Blot of NCI-H226 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PPP3R1 / Calcineurin B

PPP3R1 / Calcineurin B Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

PPP3R1 / Calcineurin B (1-170, His-tag)

PPP3R1 / Calcineurin B Human Purified > 90 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

PPP3R1 / Calcineurin B (1-170, His-tag)

PPP3R1 / Calcineurin B Human Purified > 90 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

PPP3R1 / Calcineurin B

PPP3R1 / Calcineurin B Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

PPP3R1 overexpression lysate

PPP3R1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

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