PRDM6 / PFM3 antibody

Principal name

PRDM6 / PFM3 antibody

Alternative names for PRDM6 / PFM3 antibody

PR domain zinc finger protein 6, PR domain-containing protein 6, Putative histone-lysine N-methyltransferase PRDM6

SwissProt ID

A6QPM3 (Bovin), Q3UZD5 (Mouse), Q9NQX0 (Human)

Gene ID

93166 (PRDM6)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PRDM6 / PFM3 antibody

Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ 1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ 1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ 1 is also a tumor susceptibility gene in mice. The loss of RIZ 1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ 1 promoter strongly correlated with lost or decreased RIZ 1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRDM6 / PFM3 antibody

Human Jurkat; WB Suggested Anti-PRDM6 Antibody Titration: 0.2-1 ug/ml. Positive Control: Jurkat cell lysate; PRDM6 antibody - N-terminal region (ARP51080_P050) in Human Jurkat cells using Western Blot Rabbit Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PRDM6 / PFM3 antibody

PRDM6 / PFM3 Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

PRDM6 / PFM3 antibody

Immunohistochemistry-Paraffin: ETS2 Antibody [NBP1-91022] Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

PRDM6 / PFM3 antibody

Immunohistochemistry-Paraffin: ETS2 Antibody [NBP1-91023] Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

4 Item(s)

per page
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