PRDM8 / PFM5 antibody

Principal name

PRDM8 / PFM5 antibody

Alternative names for PRDM8 / PFM5 antibody

PR domain zinc finger protein 8, PR domain-containing protein 8

SwissProt ID

Q8BZ97 (Mouse), Q9NQV8 (Human)

Gene ID

56978 (PRDM8)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Dros (Drosophila), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PRDM8 / PFM5 antibody

This product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger gene RIZ 1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ 1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ 1 is also a tumor susceptibility gene in mice. The loss of RIZ 1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ 1 promoter strongly correlated with lost or decreased RIZ 1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

General readings

Xiao,B., (2003) Curr. Opin. Struct. Biol. 13 (6), 699-705

9 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRDM8 / PFM5 antibody

WB Suggested Anti-PRDM8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PRDM8 / PFM5 antibody

WB Suggested Anti-PRDM8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PRDM8 / PFM5 antibody

WB Suggested Anti-PRDM8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PRDM8 / PFM5 (N-term) antibody

PRDM8 Antibody (N-term) (Cat. #AP53438PU-N) western blot analysis in CEM cell line lysates (35µg/lane).This demonstrates the PRDM8 antibody detected the PRDM8 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PRDM8 / PFM5 antibody

Human 293T; Host:Rabbit. Target Name:PRDM8. Sample Tissue:293T. Antibody Dilution: 1.0ug/ml.; PRDM8 antibody - N-terminal region (ARP34596_P050) in Human 293T cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PRDM8 / PFM5 antibody

Human HT1080; WB Suggested Anti-PRDM8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HT1080 cell lysate; PRDM8 antibody - N-terminal region (ARP39400_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PRDM8 / PFM5 antibody

Human HT1080; WB Suggested Anti-PRDM8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HT1080 cell lysate; PRDM8 antibody - middle region (ARP39401_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PRDM8 / PFM5 antibody

Western  Blot:  PRDM8 Antibody [NBP1-33646] – Western blot analysis of PRDM8 on HCT116 lysates using NBP1-33646 at a dilution of 1:1000. 30ug whole cell lysate loaded on 7.5% SDS PAGE gel. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PRDM8 / PFM5 antibody

Immunohistochemistry-Paraffin: PRDM8 Antibody [NBP1-92284] - Immunohistochemical staining of human testis shows strong cytoplasmic and nucleolar positivity in cells in seminiferus ducts. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

9 Item(s)

per page
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