PRDM9 / PFM6 antibody

Principal name

PRDM9 / PFM6 antibody

Alternative names for PRDM9 / PFM6 antibody

PR domain zinc finger protein 9, PR domain-containing protein 9, Histone-lysine N-methyltransferase PRDM9

SwissProt ID

P0C6Y7 (Rat), Q6P2A1 (Danre), Q96EQ9 (Mouse), Q9NQV7 (Human)

Gene ID

56979 (PRDM9), 365155 (Prdm9)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C)

Background of PRDM9 / PFM6 antibody

PR domain containing 9 protein (PRDM9) is one of at least 20 PR domain containing molecules in human (1). The PR domain is a derivative of SET domain which has been known to act as catalytic domain for histone lysine methylation (2). PRDM9 is located on human chromosome 5p14, it contains a PR domain in its N-terminal portion and a C2H2 type zinc finger motif in its C-terminal portion (3). A PR domain’s catalytic activity for histone methylation is dependent upon the individual proteins of that PR domain. The catalytic activity of PRDM9 towards histone H3 is restricted only for tri-methylation of lysine 4 in histone H3 (H3K4) from di-methylation (4). Tri-methylation of H3K4 is a characteristic trait of transcriptionally active genes (5); therefore, PRDM9 is often implicated in transcriptional regulation. PRDM9 also plays an essential role on proper progression of meiotic prophase in mouse germ cell lineage (4).
Recent study has reported that PRDM9 is expressed in early meiosis and it controls the activation of mammalian recombination hotspots (6). Mammalian meiotic recombination occurs at these hotspots, ensuring the orderly segregation of meiotic chromosome and thus creating genetic variation among offspring. Therefore, deficiency of PRDM9 in mice resulted in sterility in both sexes (6). PRDM9 mutations in human can cause failure in spermatogenesis and thus idiopathic infertility in human males (7). PRDM9 is expressed in germ cells entering meiotic prophase. It is approximately a 46.1kDa protein (384 amino acids).

General readings

Sun,X.J., (er) PLoS ONE 3 (1), E1499 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRDM9 / PFM6 antibody

WB Suggested Anti-PRDM9 Antibody Titration: 1 ug/ml; Positive Control: 293T cells lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PRDM9 / PFM6 antibody

Human Placenta; Rabbit Anti-PRDM9 Antibody. Catalog Number: arp35967. Paraffin Embedded Tissue: Human Placenta. Antibody Concentration: 5 ug/ml; PRDM9 antibody - middle region (ARP35967_P050) in Human Placenta cells using Immunohistochemistry Rabbit Aff - Purified Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

PRDM9 / PFM6 (440-451) antibody

TA320212 (2µg/ml) staining of Rat Ovary lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PRDM9 / PFM6 Control Peptide

PRDM9 / PFM6
0.1 mg / €250.00
  Acris Antibodies GmbH

PRDM9 / PFM6 antibody

Western Blot of PRDM9 antibody (Cat#AP09867PU-N) at 1/500 dilution. Rabbit Aff - Purified Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

PRDM9 / PFM6 antibody

PRDM9 / PFM6 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PRDM9 / PFM6 antibody

PRDM9 / PFM6 Rabbit Aff - Purified Hu P, WB
50 µg / €440.00
  Novus Biologicals Inc.

7 Item(s)

per page
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