PREB antibody

Principal name

PREB antibody

Alternative names for PREB antibody

SEC12, Prolactin regulatory element-binding protein, Mammalian guanine nucleotide exchange factor mSec12

SwissProt ID

Q9HCU5 (Human), Q9WTV0 (Rat), Q9WUQ2 (Mouse)

Gene ID

10113 (PREB), 3030197 (argB)

Available reactivities

Ms (Mouse), Bov (Bovine), Can (Canine), Hu (Human), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PREB antibody

Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins.
A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.

General readings

General / background references:Taylor Clelland CL et al. Mapping and developmental expression analysis of the WD-repeat gene Preb. Genomics 63:391-9 (2000). PubMed PMID: 10704286

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PREB antibody

WB Suggested Anti-PREB Antibody Titration: 0.2-1 ug/ml; Positive Control: Raji cell lysatePREB is supported by BioGPS gene expression data to be expressed in Raji Rabbit IgG Purified Can, Eq, GP, Hu, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PREB antibody

Host: Rabbit; Target Name: Preb; Sample Tissue: Mouse Liver lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

PREB antibody

PREB Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PREB antibody

Human Heart; . Rabbit Anti-PREB Antibody. . Catalog Number:. ARP34130 . Paraffin Embedded Tissue: Human cardiac cell . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; PREB antibody - N-terminal region (ARP34130_P050) in Human Heart cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

PREB antibody

Western Blot: PREB Antibody [NB120-3422] - Figure 1 shows a Western blot of recombinant mouse PREB using NB120-3422. Rabbit IgG Purified Ms WB
0.1 ml / €400.00
  Novus Biologicals Inc.

PREB antibody

Immunohistochemistry-Paraffin: PREB Antibody [NBP1-87056] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PREB antibody

Immunohistochemistry-Paraffin: PREB Antibody [NBP1-87057] - Immunohistochemical staining of human liver shows strong nuclear and cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PREB

PREB Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PREB

PREB Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

PREB

PREB Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PREB

PREB Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PREB overexpression lysate

PREB overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

12 Item(s)

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