Presenilin-1 antibody

Principal name

Presenilin-1 antibody

Alternative names for Presenilin-1 antibody

Presenilin 1, PSEN1, PS1, AD3, Alzheimer Disease 3, PS-1, PSNL1, AF3, FAD, S182

SwissProt ID

P49768 (Human), P49769 (Mouse), P97887 (Rat), Q4JIM4 (Chick), Q6RH31 (Canfa), Q9XT97 (Bovin)

Gene ID

5663 (PSEN1)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Hst (Hamster), Bov (Bovine), Prim (Primate), Rb (Rabbit), Can (Canine), GP (Guinea Pig), Por (Porcine)

Available hosts

Mouse, Chicken, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Presenilin-1 antibody

In Alzheimer’s disease (AD) a progressive neurodegeneration and cognitive decline occurs during the course of the disease and amylloid beta-peptide (Abeta) is believed to play a central role for the molecular pathogenesis of AD. The gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into Abeta. Abeta accumulates in brain and forms plaques in AD brains. One of the mechanism behind neurodegenration in AD is apoptosis due to preservation of gamma secretase activity. Several proteins (presenilin1, presenilin 2, nicastrin, Aph-1 and Pen-2) interact with gamma secretase complex during apoptosis in neuronal cells to make active gamma secretase complexes in apoptotic cells. The fragments corresponding to the PS1 N-terminal fragment and the caspase-cleaved PS1 C-terminal fragment (PS1-caspCTF) were found to form active gamma-secretase complexes when co-expressed in presenilin (PS) knockout cells (1). Mutations in presenilin 1 (PS1) lead to dominant inheritance of early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology and altered intracellular Ca(2+) homeostasis involving endoplasmic reticulum Ca(2+) stores (2, 3). It is suggested that Presenilin binds to phospholipase D1 through its loop region thereby recruiting golgi/transgolgi network that perturbs gamma secretase activity and Abeta formation.
Numerous mutations in the presenilins are known to cause early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology in transgenic mouse models. Presenelin 1is a 467 amino acid membrane bound protein with 8 putative TMD. It is believed to be the catalytic domain of gamma secretase complex that catalyzes the intramembrane cleavage of integral membraneproteins such as Notch receptors and beta amyloid precursor protein. Other functions include intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Some regulatory proteins associated with Resenelin are Nicastrin, NTF, CTF, APH1/2and PEN2. It also interacts with other proteins such as Notch1, cadherin 1, plakophilin 4, dock 3, catenin, HERPUD1, FLNA and FLNB.

General readings

General / background references:Diehlmann A et al. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. J Neurosci Res 56:405-19 (1999). PubMed PMID: 10340748

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Presenilin-1+2 (C-term) antibody

Human Placenta (formalin-fixed, paraffin-embedded) stained with PSEN1 antibody AP22785PU-N followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Presenilin-1 (N-term) antibody

AP15743PU Presenilin 1 antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

Presenilin-1 (N-term) antibody

AP15743PU Presenilin 1 antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

Presenilin-1 (N-term) antibody

AP15743PU Presenilin 1 antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
0.1 ml / €180.00
  Acris Antibodies GmbH

Presenilin-1 antibody

Western blot analysis of presenilin1 in human brain lysate with presenilin1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Presenilin-1 antibody

Western blot analysis of extracts from mouse heart cells, using presenilin 1 antibody (#TA313388).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Presenilin-1 antibody

WB Suggested Anti-PSEN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: OVCAR-3 cell lysate;PSEN1 is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells Rabbit IgG Purified Can, GP, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Presenilin-1 antibody

Western Blot: Presenilin 1 Antibody [TA336586] - Analysis of Human Presenilin 1 / PSDR1 in androgen-stimulated metastatic adenocarcinoma LNCaP.FGC cells with Presenilin 1 antibody at a dilution of 1:500 Rabbit Purified Hu C, E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Presenilin-1 antibody

Western blot analysis on RAW264.7 cell lysate using Presenilin 1 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Presenilin-1 antibody

Immunohistochemical staining of human brain with Rabbit anti Human presenilin-1 (AP05739PU-N) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Presenilin-1 antibody

Immunohistochemistry (IHC) analyzes of Presenilin 1 antibody (Cat.-No.: AP06290PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Presenilin-1 antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Presenilin-1 control peptide

Presenilin-1
0.25 mg / €250.00
  Acris Antibodies GmbH

Presenilin-1 (N-term) antibody

Presenilin-1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Presenilin-1 control peptide

Presenilin-1
0.25 mg / €250.00
  Acris Antibodies GmbH

Presenilin-1 (C-term) antibody

Presenilin-1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Presenilin-1 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms E, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Presenilin-1 Control Peptide

Presenilin-1
50 µg / €160.00
  Acris Antibodies GmbH

Presenilin-1 antibody

Presenilin-1 Rabbit Serum Hu, Mky C, IP, WB
0.1 ml / €330.00
  Acris Antibodies GmbH

Presenilin-1 (N-term) antibody

Presenilin-1 Rabbit Serum Hst, Hu, Mky C
0.1 ml / €340.00
  Acris Antibodies GmbH

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