Presenilin-2 antibody

Principal name

Presenilin-2 antibody

Alternative names for Presenilin-2 antibody

Presenilin 2, PSEN2, AD4, Alzheimer disease 4, PS2, PSNL2, STM2, STM-2, E5-1, AD3LP, AD5

SwissProt ID

O88777 (Rat), P49810 (Human), Q0MS45 (Pig), Q61144 (Mouse), Q90X07 (Chick), Q9XT96 (Bovin)

Gene ID

5664 (PSEN2), 19165 (Psen2), 81751

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E)

Background of Presenilin-2 antibody

In Alzheimer’s disease (AD) a progressive neurodegeneration and cognitive decline occurs during the course of the disease and amylloid beta-peptide (Abeta) is believed to play a central role for the molecular pathogenesis of AD. The gamma-Secretase is a key enzyme involved in the processing of the beta-amyloid precursor protein into Abeta. Abeta accumulates in brain and forms plaques in AD brains. One of the mechanism behind neurodegenration in AD is apoptosis due to preservation of gamma secretase activity. Several proteins (presenilin1, presenilin 2, nicastrin, Aph-1 and Pen-2) interact with gamma secretase complex during apoptosis in neuronal cells to make active gamma secretase complexes in apoptotic cells.
Presenilin 2 is cleaved by caspase 3 to generate a 22 amino acid presenilin-loop peptide (PLP, 308-329 of presenilin 2) in cells undergoing apoptosis. Recent studies have shown that PLP caused a rapid release of calcium stores form the endoplasmic reticulum and suggest that intracellular release of calcium homeostasis may be an important link to acceleration of apoptosis (2). PLP and presenilin 2 may be an important therapeutic too for cancer and degenerative diseases. It is suggested that Presenilin 2 binds to InsP3 pathway. Numerous mutations in the presenilin 1 and 2 are known to cause early-onset familial Alzheimer’s disease (FAD). These mutations are known to alter the gamma-secretase cleavage of the amyloid precursor protein (APP), resulting in increased ratio of Abeta42/Abeta40 and accelerated amyloid plaque pathology in transgenic mouse models. Presenelin 2 is a 447 amino acid membrane bound protein with 8 putative TMD. It is believed to be the catalytic domain of gamma secretase complex that catalyzes the intramembrane cleavage of integral membraneproteins such as Notch receptors and beta amyloid precursor protein. Other functions include intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Some regulatory proteins associated with Resenelin are Nicastrin, NTF, CTF, APH1/2and PEN2. It also interacts with other proteins such as Notch1, cadherin 1, plakophilin 4, dock 3, catenin, HERPUD1, FLNA and FLNB.

General readings

da (2005) Curr Alzheimer Res 2 (5), 507-514

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Presenilin-2 antibody

WB Suggested Anti-PSEN2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Presenilin-2 antibody

Host: Rabbit; Target name: Psen2; Sample Tissue: Rat Stomach lysates; Antibody Dilution: 1.0ug/mL Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Presenilin-2 antibody

Western Blot: Presenilin 2 Antibody (198C679.2.) [TA336445] - analysis for Presenilin-2 using this antibody. A protein band of approximate molecular weight of 55 kDa was detected. Mouse IgM 198C679.2. Supernatant Hu WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

Presenilin-2 antibody

Western blot using Clone PS2 to detect both endogenous PS2 in HEK293 cells and transfected Human PS2 in another cell line. Photo courtesy of P. Fraser. Mouse IgG1 PS2 Purified Hu, Ms ICC/IF, WB
1 ml / €379.00
  OriGene Technologies, Inc.

Presenilin-2 antibody

Presenilin-2 Goat Serum Hu C, E, P
0.1 ml / €450.00
  Acris Antibodies GmbH

Presenilin-2 control peptide

Presenilin-2
0.1 mg / €250.00
  Acris Antibodies GmbH

Presenilin-2 antibody

Presenilin-2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Presenilin-2 antibody

Presenilin-2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Presenilin-2 antibody

Western blot analysis for PSEN2. Using PSEN2 monoclonal antibody, clone 198C679.2. ( Cat # MAB0101 ) at 1 : 500 against 30 µg/lane of HL-60 cell lysate. A protein band of approximate molecular weight of 55 kDa was detected. Mouse IgM 198C679.2. Hu WB
0.2 ml / €400.00
  Abnova Taiwan Corp.

Presenilin-2 antibody

Human kidney; PSEN2 antibody - N-terminal region (ARP44289_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

Presenilin-2 antibody

Presenilin-2 Rabbit IgG Aff - Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

Presenilin-2 antibody

Presenilin 2 staining in paraffin-embedded human brain, showing both nuclear and cytoplasmic protein localization. Data courtesy of Cell Signaling Technology, Inc. Rabbit Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 ml / €400.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

PSEN2 - human gene knockout kit via CRISPR

PSEN2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PSEN2 - human gene knockout kit via CRISPR

PSEN2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PSEN2 - human gene knockout kit via CRISPR

PSEN2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PSEN2 - human gene knockout kit via CRISPR

PSEN2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Psen2 - mouse gene knockout kit via CRISPR

Psen2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Psen2 - mouse gene knockout kit via CRISPR

Psen2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Psen2 - mouse gene knockout kit via CRISPR

Psen2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Psen2 - mouse gene knockout kit via CRISPR

Psen2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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