PRKAR2A antibody

Principal name

PRKAR2A antibody

Alternative names for PRKAR2A antibody

PRKAR2, PKR2, protein kinase A RII-alpha, PKA RII, PKA R2, cAMP-dependent protein kinase type II-alpha regulatory subunit

SwissProt ID

O49196 (Arath), P00515 (Bovin), P05207 (Pig), P12367 (Mouse), P12368 (Rat), P13861 (Human)

Gene ID

100139910 (PRKAR2A), 5576, 29699 (Prkar2a)

Available reactivities

Bov (Bovine), Hu (Human), Por (Porcine), Ms (Mouse), Can (Canine), Mky (Monkey), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of PRKAR2A antibody

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Cα, Cβ and Cγ, that each represent specific gene products. Cα and Cβ are closely related (93% amino acid sequence similarity), where as Cγ displays 83% and 79% similarity to Cα and Cβ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.

General readings

Yang H., et al. (2013) J. Biol. Chem. 288 (12), 8737-8749

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI5F1 (formerly 5F1)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501195, Dilution 1:50) Mouse IgG1 OTI5F1 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1G7 (formerly 1G7)  
Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501104, Dilution 1:50) Mouse IgG1 OTI1G7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1C4 (formerly 1C4)  
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501106, Dilution 1:50) Mouse IgG1 OTI1C4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1A7 (formerly 1A7)  
Immunohistochemical staining of paraffin-embedded pancreas tissue within the normal limits using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501129, Dilution 1:50) Mouse IgG1 OTI1A7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1B4 (formerly 1B4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501143, Dilution 1:50) Mouse IgG1 OTI1B4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI4A3 (formerly 4A3)  
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501144, Dilution 1:50) Mouse IgG1 OTI4A3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  anti-PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI4H8 (formerly 4H8)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501145, Dilution 1:50) Mouse IgG1 OTI4H8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

  PRKAR2A (PKA R2 ) mouse monoclonal antibody, clone OTI1F8 (formerly 1F8)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-PRKAR2A mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501146) Mouse IgG1 OTI1F8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKAR2A antibody

Western blot (WB) analysis of PKA IIα reg antibody (Cat.-No.: AP06667PU-N) in extracts from 293 cells. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PRKAR2A antibody

Western blot analysis of extracts from 293/HepG2 cells, using KAP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

PRKAR2A antibody

Western blot analysis of extracts from 293/HepG2 cells, using KAP2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

PRKAR2A antibody

PRKAR2A Mouse IgG1 RS-6 Purified Bov, Hu, Por E, FN, ICC/IF
1 mg / €310.00
  HyTest Ltd.

PRKAR2A antibody

PRKAR2A Mouse IgG2a RS-17 Purified Bov, Hu, Por E, ICC/IF
1 mg / €310.00
  HyTest Ltd.

PRKAR2A antibody

PRKAR2A Mouse IgG2a RS-30 Purified Bov, Hu, Por E, FN, ICC/IF
1 mg / €310.00
  HyTest Ltd.

CRISPR

Catalog No. Species Donor Vector  

PRKAR2A - human gene knockout kit via CRISPR

PRKAR2A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRKAR2A - human gene knockout kit via CRISPR

PRKAR2A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRKAR2A - human gene knockout kit via CRISPR

PRKAR2A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRKAR2A - human gene knockout kit via CRISPR

PRKAR2A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PRKAR2A

  Recombinant protein of human protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A)  
PRKAR2A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PRKAR2A (1-404, His-tag)

PRKAR2A Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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