PRKD2 / PKD2 antibody

Principal name

PRKD2 / PKD2 antibody

Alternative names for PRKD2 / PKD2 antibody

PKC-D2, nPKC-D2, HSPC187, Serine/threonine-protein kinase D2

SwissProt ID

Q5XIS9 (Rat), Q8BZ03 (Mouse), Q9BZL6 (Human)

Gene ID

5311 (PKD2), 25865 (PRKD2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PRKD2 / PKD2 antibody

PKD2, a member of the polycystin family, functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. PKD2 interacts with PKD1, potentially through the C-terminal region. PKD1 requires the presence of PKD2 for stable expression. PKD2 also interacts with CD2AP. This protein is strongly expressed in ovary, fetal and adult kidney, testis, and small intestine, but is not detected in peripheral leukocytes. Defects in PKD2 are the cause of autosomal dominant polycystic kidney disease type II (ADPKD-2) which represent approximately 15% of cases of autosomal dominant polycystic kidney disease, a common autosomal dominant genetic disease affecting about 1 out 1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. All mutations, scattered between exons 1 and 11, result in a truncated PKD2 that lacks both the calcium-binding EF-hand domain and the two cytoplasmic domains required for the interaction of PKD2 with PKD1 and with itself. ADPKD type II is clinically milder than ADPKD type I, but it has a deleterious impact on overall life expectancy.

General readings

Sturancy S. Et al. J Biol Chem 2001 Feb 2;276(5):3310-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRKD2 / PKD2 antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA308724 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PRKD2 / PKD2 antibody

Anti-PRKD2 mouse monoclonal antibody (TA501647) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2(RC215335). Mouse IgG1 OTI3F7 Purified Can, Hu, Mky, Rt F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-PRKD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501648) Mouse IgG2b OTI5A3 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-PRKD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501672, Dilution 1:50) Mouse IgG2b OTI5G1 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PRKD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501684, Dilution 1:50) Mouse IgG2a OTI4F1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

Anti-PRKD2 mouse monoclonal antibody (TA501775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2(RC215335). Mouse IgG1 OTI3B12 Purified Can, Hu, Mky, Rt F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 (C-term) antibody

Human Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PRKD2 / PKD2 antibody

Western blot analysis of extracts from NIH/3T3 cells, treated with PMA (250ng/ml, 15mins), using PKD2 (Ab-876) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PRKD2 / PKD2 antibody

PRKD2 / PKD2 Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

PRKD2 / PKD2 antibody

Anti-PRKD2 mouse monoclonal antibody (TA501625) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PRKD2(RC215335). Mouse IgG2a OTI2E2 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PRKD2 (RC215335, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRKD2. Mouse IgG2b OTI3A1 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PRKD2 / PKD2 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 2E4 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PRKD2 / PKD2 antibody

Western blot analysis of PKD2 Antibody (Cat.-No AP06570PU-N) in extracts from NIH/3T3 cells treated with PMA 250ng/ml 15'. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PRKD2 / PKD2 (C-term) antibody

AP14814PU-N PKD2 antibody staining of Formalin-Fixed, Paraffin-Embedded Human cancer tissue. This primary antibody was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PRKD2 / PKD2 antibody

Western Blot analysis of PRKD2 expression in transfected 293T cell line (H00025865-T01) by PRKD2 MaxPab polyclonal antibody.

Lane 1: PRKD2 transfected lysate(96.58 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PRKD2 / PKD2 antibody

Immunoperoxidase of monoclonal antibody to PRKD2 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml] Mouse IgG2b 2E4 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PRKD2 / PKD2 antibody

PRKD2 / PKD2 Mouse IgG2b 2E4 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

PRKD2 / PKD2 pSer876 antibody

Western blot analysis of extracts from NIH-3T3 cells treated with PMA 250ng/ml 15', using PKD2 (Phospho-Ser876) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

PRKD2 / PKD2 pSer876 antibody

Western blot analysis of extracts from NIH-3T3 cells treated with PMA 250ng/ml 15', using PKD2 (Phospho-Ser876) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

PRKD2 / PKD2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PKD2 (Ab-876) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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