Progesterone receptor antibody

Principal name

Progesterone receptor antibody

Alternative names for Progesterone receptor antibody

PR, PGR, NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3

SwissProt ID

P06186 (Rabit), P06401 (Human), P07812 (Chick), Q00175 (Mouse), Q28590 (Sheep), Q63449 (Rat), Q9GLW0 (Canfa)

Gene ID

5241 (PGR), 25154 (Pgr)

Available reactivities

Hu (Human), Rt (Rat), Eq (Equine), Por (Porcine), Ms (Mouse), Chk (Chicken), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Progesterone receptor antibody

The progesterone receptor (also known as NR3C3) is a member of the steroid or nuclear hormone receptor superfamily family of proteins. Family members are involved in diverse physiological functions including embryonic development, cell differentiation, and homeostasis. The receptors function by binding to DNA in the nucleus and regulating the transcription of target genes. The progesterone receptor is activated by its ligand progesterone, which is a steroid hormone involved in the menstrual cycle, pregnancy and embryogenesis. Progesterone receptor expression status is commonly used as a marker for classifying breast cancers and for predicting prognosis and response to endocrine therapy. That is, antibody positive versus antibody negative tumors can have potential implications with respect to predicted outcome, treatment, or disease monitoring. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). These isoforms are generated from alternative transcriptional start sites within the progesterone receptor gene. Both forms are ligand activated by progesterone although they differ in their relative ability to activate target gene transcription. Antibody to progesterone receptor is widely used to study breast and other progesterone receptor containing tissues such as the endometrium. Researchers are encouraged to consult the scientific literature for additional information regarding the use of antibody to measure progesterone receptor as part of assessing breast or other tumor types.

General readings

Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)
Tang, P., et al. Cancer Invest. 28(9):978-982(2010)
Van Belle, V., et al. J. Clin. Oncol. 28(27):4129-4134(2010)
Taylor, K.C., et al. Horm Res Paediatr (2010) In press
Near, A.M., et al. Fertil. Steril. (2010) In press

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Progesterone receptor antibody

Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 n.a Purified Hu, Mky, Ms, Rt ICC/IF, IP, P, WB
0.125 ml / €470.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Immunofluorescent staining of MCF-7 cells using anti-PGR mouse monoclonal antibody (UM800036, green, 1:50). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner. Mouse IgG2a UMAB135 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800037; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB136 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800038; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG2a UMAB137 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunofluorescent staining of MCF-7 cells using anti-PGR mouse monoclonal antibody (UM800036, green, 1:50). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner. Mouse IgG2a UMAB135 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800037; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB136 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800038; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG2a UMAB137 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Human Breast Carcinoma stained with anti-Progesterone Receptor (PR) antibody. Rabbit SP42 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802606) Mouse IgG1 OTI2E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PGR mouse monoclonal antibody. (TA802702; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI4B3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802704) Mouse IgG1 OTI11E8 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802713) Mouse IgG1 OTI2F8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802714) Mouse IgG2a OTI5C12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 3E11 Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml] Mouse IgG1 2C2 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml] Mouse IgG1 1B11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 5D10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 4E9 Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma(4 μm) stained with anti-Progesteron antibody (DB 059) antibody shows strong positive nuclear immunostaining of tumor cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P21-S Aff - Purified Hu P
0.1 ml / €320.00
  DB Biotech, spol. s r.o.

Sample sizes available

Progesterone receptor (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma(4 μm) stained with anti-Progesteron antibody (DB 059) antibody shows strong positive nuclear immunostaining of tumor cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P21-S Aff - Purified Hu P
0.2 ml / €440.00
  DB Biotech, spol. s r.o.

Sample sizes available

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