Progesterone receptor antibody

Principal name

Progesterone receptor antibody

Alternative names for Progesterone receptor antibody

PR, PGR, NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3

SwissProt ID

P06186 (Rabit), P06401 (Human), P07812 (Chick), Q00175 (Mouse), Q28590 (Sheep), Q63449 (Rat), Q9GLW0 (Canfa)

Gene ID

5241 (PGR), 396198, 250 (ALPP)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Chk (Chicken), GP (Guinea Pig), Re (Reptiles), Eq (Equine), Prim (Primate), Sh (Sheep), Por (Porcine), Hst (Hamster), Mky (Monkey)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Progesterone receptor antibody

The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. When bound to DNA, PgR can positively or negatively regulate gene transcription through the recruitment of coactivator (e.g. SRC 1) or corepressor (e.g. NCoR) proteins. PgR is phosphorylated on multiple serine residues through distinct groups of sites regulated by hormone and different kinases.
Progesterone receptor is present in the CNS in monoenzymatic aromatic L amino acid decarboxylase (AADC) containing cells of the preoptic area and also in neurons expressing both AADC and tyrosine hydroxylase (TH) in the arcuate nucleus. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
There is extensive documentation that both avian and mammalian PR isolated from tissue soluble extracts can exist in one of two different molecular forms A and B. Human PR consists of a 94 kDa A form and a 120 kDa B form. Chicken PR consists of a 78 kDa A form and a 110 kDa B form. Alpha PR6 reacts with both the 120 kDa B form of human PR and the 110 kDa B form of chicken PR.

General readings

This product has been used in:Smith CL et al. Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structure. J Biol Chem 272:14227-35 (1997). PubMed PMID: 9162055
Dao-Phan HP et al. Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid. Mol Endocrinol 11:962-72 (1997). PubMed PMID: 9178755
Prapapanich V et al. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. Mol Endocrinol 10:420-31 (1996). PubMed PMID: 8721986
Johnson JL & Toft DO Binding of p23 and hsp90 during assembly with the progesterone receptor. Mol Endocrinol 9:670-8 (1995). PubMed PMID: 8592513
Johnson JL et al. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol 14:1956-63 (1994). PubMed PMID: 8114727
Johnson JL & Toft DO A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem 269:24989-93 (1994). PubMed PMID: 7929183
Weigel NL et al. Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays. Mol Endocrinol 6:8-14 (1992). PubMed PMID: 1738374
Chandran UR & DeFranco DB Internuclear migration of chicken progesterone receptor, but not simian virus-40 large tumor antigen, in transient heterokaryons. Mol Endocrinol 6:837-44 (1992). PubMed PMID: 1603089
Power RF et al. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254:1636-9 (1991). PubMed PMID: 1749936
Smith DF et al. Reconstitution of progesterone receptor with heat shock proteins. Mol Endocrinol 4:1704-11 (1990). PubMed PMID: 2280772
Sullivan WP et al. Preparation of monoclonal antibodies to the avian progesterone receptor. Eocrinology 119:1549-57 (1986). PubMed PMID: 2428599

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Progesterone receptor antibody

Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 n.a Purified Hu, Mky, Ms, Rt ICC/IF, IP, P, WB
0.125 ml / €470.00
  Acris Antibodies GmbH

Progesterone receptor antibody

Immunofluorescent staining of MCF-7 cells using anti-PGR mouse monoclonal antibody (UM800036, green, 1:50). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner. Mouse IgG2a UMAB135 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800037; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB136 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800038; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG2a UMAB137 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunofluorescent staining of MCF-7 cells using anti-PGR mouse monoclonal antibody (UM800036, green, 1:50). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner. Mouse IgG2a UMAB135 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800037; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG1 UMAB136 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (UM800038; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min) Mouse IgG2a UMAB137 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802606) Mouse IgG1 OTI2E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PGR mouse monoclonal antibody. (TA802702; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI4B3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802704) Mouse IgG1 OTI11E8 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802713) Mouse IgG1 OTI2F8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA802714) Mouse IgG2a OTI5C12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 3E11 Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml] Mouse IgG1 2C2 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml] Mouse IgG1 1B11 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 5D10 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor antibody

Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] Mouse IgG1 4E9 Purified Hu, Rt E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Progesterone receptor (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma(4 μm) stained with anti-Progesteron antibody (DB 059) antibody shows strong positive nuclear immunostaining of tumor cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P21-S Aff - Purified Hu P
0.1 ml / €320.00
  DB Biotech, spol. s r.o.

Sample sizes available

Progesterone receptor (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma(4 μm) stained with anti-Progesteron antibody (DB 059) antibody shows strong positive nuclear immunostaining of tumor cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P21-S Aff - Purified Hu P
0.2 ml / €440.00
  DB Biotech, spol. s r.o.

Sample sizes available

Progesterone receptor (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma(4 μm) stained with anti-Progesteron antibody (DB 059) antibody shows strong positive nuclear immunostaining of tumor cells. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P21-S Aff - Purified Hu P
0.5 ml / €550.00
  DB Biotech, spol. s r.o.

Sample sizes available

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