Protein ALEX antibody

Principal name

Protein ALEX antibody

Alternative names for Protein ALEX antibody

GNAS, GNAS1, AHO, GSA, GSP, POH, GPSA, NESP, PHP1A, PHP1B, PHP1C, C20orf45, Alternative gene product encoded by XL-exon

SwissProt ID

P84996 (Human), Q6R0H6 (Mouse), Q9Z213 (Rat)

Gene ID

2778 (GNAS), 14683 (Gnas)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Protein ALEX antibody

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Protein ALEX antibody

Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308888 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

3Hum. Fetal Heart; Host: Rabbit; Target Name: GNAS; Sample Tissue: Human Fetal Heart; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Sample (50 ug of whole cell lysate). . A: Mouse brain. . 10% SDS PAGE. . TA308889 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Western blot analysis of Jurkat cell using TA323636(GNAS Antibody) at dilution 1/200 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Western blot analysis of Mouse brain tissue using TA323637(GNAS Antibody) at dilution 1/500 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Protein ALEX Rabbit IgG Purified Hu, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Western blot analysis of extracts of various cell lines, using GNAS antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Protein ALEX antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between GNAS and ADCY2. HeLa cells were stained with anti-GNAS rabbit purified polyclonal 1:1200 and anti-ADCY2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

GNAS - human gene knockout kit via CRISPR

  GNAS - human gene knockout kit via CRISPR  
GNAS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GNAS - human gene knockout kit via CRISPR

  GNAS - human gene knockout kit via CRISPR  
GNAS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GNAS - human gene knockout kit via CRISPR

  GNAS - human gene knockout kit via CRISPR  
GNAS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GNAS - human gene knockout kit via CRISPR

  GNAS - human gene knockout kit via CRISPR  
GNAS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Protein ALEX

Protein ALEX Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Protein ALEX

Protein ALEX Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GNAS (mGFP-tagged)-Human GNAS complex locus (GNAS), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GNAS (mGFP-tagged)-Human GNAS complex locus (GNAS), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, GNAS (mGFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, GNAS (mGFP-tagged) - Human GNAS complex locus (GNAS), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

Lenti ORF particles, GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GNAS (Myc-DDK-tagged)-Human GNAS complex locus (GNAS), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, GNAS (Myc-DDK tagged) - Human GNAS complex locus (GNAS), transcript variant 6 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GNAS (Myc-DDK tagged) - Human GNAS complex locus (GNAS), transcript variant 6 , 200 uL, >10^7 TU/mL  
200 µl / €870.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gnas (GFP-tagged) - Mouse GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 8, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gnas (GFP-tagged) - Mouse GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 8, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gnas (Myc-DDK-tagged) - Mouse GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 7, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gnas (Myc-DDK-tagged) - Mouse GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), transcript variant 7, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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