Protein C / PROC antibody

Principal name

Protein C / PROC antibody

Alternative names for Protein C / PROC antibody

Vitamin K-dependent protein C, Anticoagulant protein C, PROC1, Autoprothrombin IIA, Blood coagulation factor XIV, Inactivator of coagulation factors Va and VIIIa

SwissProt ID

P00745 (Bovin), P04070 (Human), P31394 (Rat), P33587 (Mouse), Q28278 (Canfa), Q28380 (Horse), Q28412 (Felca), Q28661 (Rabit), Q9GLP2 (Pig)

Gene ID

5624 (PROC), 5624357 (acpS), 19123 (Proc)

Available reactivities

Hu (Human), Bov (Bovine), Rb (Rabbit), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat, Sheep, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunodiffusion (ID), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of Protein C / PROC antibody

Protein C is a glycoprotein (MW 60,000) which is synthesized in the liver. It acts as a trypsin like serine protease but functions in a manner different from that of antithrombin III. Activated protein C (pCa) results from proteolytic cleavage of protein C by thrombin and with protein S (pS) as a cofactor it cleaves factors Va and VIIIa, producing anti-coagulation by decreasing the conversion of prothrombin to thrombin. It also stimulates the fibrinolytic system by inactivating the inhibitor of tissue plasminogen activator (TPA), an enzyme that converts plasminogen into plasmin which cleaves fibrin into fibrin split products. Protein C is consumed during coagulation in vivo. Very little protein C is activated during coagulation in vitro, because this requires the presence of thrombomodulin, a thrombin receptor on endothelial cells. The coagulant activity of protein C is species specific and pCa is specifically regulated by protein C inhibitor (pCI) in the presence of heparin.
Normal human plasma contains an average of 0.3 mg/ml. The normal newborn has a protein C level that is 30 to 40% of the normal adult level. Numerous cases with a genetical protein C eficiency associated with thrombotic disease have been reported, frequently with an extensive family history of thrombosis. Patients with a partial protein C deficiency are subject to severe, recurrent deep venous thrombosis and pulmonary embolism. The plasma protein C level should be determined before beginning anticoagulation therapy. Total protein C deficiency in the newborn leads to purpurea fulminans; the diagnosis may be confirmed by determining the protein C levels in both heterozygous parents. Acquired protein C deficiency may result of treatment with oral anticoagulants and of various liver diseases. Plasma protein C levels may also decrease after intravascular coagulation.

General readings

Russell,J.A., (2008) Hum. Genet. 123 (6), 661-663

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Protein C / PROC antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308939 diluted at 1:3000 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

Western blot analysis of extracts from K562 cells, using PROC (light chain, Cleaved-Leu179) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

Western blot analysis of extracts of ES-2 cell lines, using PROC antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

Protein C / PROC Mouse IgG2b HLW-C Aff - Purified Hu E
0.5 mg / €440.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Mouse IgG1 CaC-11 Purified Hu E, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Goat Serum Hu ID, IP
1 ml / €430.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Sheep Ig Fraction Hu WB
1 ml / €350.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Western Blot analysis of PROC expression in transfected 293T cell line (H00005624-T01) by PROC MaxPab polyclonal antibody.

Lane 1: PROC transfected lysate(50.71 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Western Blot analysis of PROC expression in transfected 293T cell line (H00005624-T01) by PROC MaxPab polyclonal antibody.

Lane 1: PROC transfected lysate(52.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

PROC monoclonal antibody (M01), clone 3A10. Western Blot analysis of PROC expression in human liver. Mouse IgG1 3A10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Rat IgG Ms E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Rat IgG Ms E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Rat B127M Ms E, WB
0.1 mg / €510.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Rat B128M Ms E, WB
0.1 mg / €510.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Sheep Ms E, WB
1 mg / €390.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Protein C / PROC Sheep Ms E, WB
0.2 mg / €400.00
  Abnova Taiwan Corp.

Protein C / PROC antibody

Transfected 293T; WB Suggested Anti-PROC Antibody Titration: 2.5ug/ml. Positive Control: Transfected 293T; PROC antibody - N-terminal region (ARP41701_T100) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Bov, Hu WB
0.1 mg / €310.00
  AVIVA Systems Biology

Protein C / PROC antibody

Hum. Adult Placenta; Host:Rabbit. Target Name:PROC. Sample Tissue:Human Adult Placenta. Antibody Dilution: 1.0ug/ml.; PROC antibody - middle region (ARP41702_P050) in Hum. Adult Placenta cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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