Protein C / PROC antibody

Principal name

Protein C / PROC antibody

Alternative names for Protein C / PROC antibody

Vitamin K-dependent protein C, Anticoagulant protein C, PROC1, Autoprothrombin IIA, Blood coagulation factor XIV, Inactivator of coagulation factors Va and VIIIa

SwissProt ID

P00745 (Bovin), P04070 (Human), P31394 (Rat), P33587 (Mouse), Q28278 (Canfa), Q28380 (Horse), Q28412 (Felca), Q28661 (Rabit), Q9GLP2 (Pig)

Gene ID

5624 (PROC), 19123 (Proc), 25268

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rb (Rabbit), Mky (Monkey), Rt (Rat)

Available hosts

Sheep, Mouse, Rat, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunodiffusion (ID), Immunoprecipitation (IP), Paraffin Sections (P)

Background of Protein C / PROC antibody

Protein C is a glycoprotein (MW 60,000) which is synthesized in the liver. It acts as a trypsin like serine protease but functions in a manner different from that of antithrombin III. Activated protein C (pCa) results from proteolytic cleavage of protein C by thrombin and with protein S (pS) as a cofactor it cleaves factors Va and VIIIa, producing anti-coagulation by decreasing the conversion of prothrombin to thrombin. It also stimulates the fibrinolytic system by inactivating the inhibitor of tissue plasminogen activator (TPA), an enzyme that converts plasminogen into plasmin which cleaves fibrin into fibrin split products. Protein C is consumed during coagulation in vivo. Very little protein C is activated during coagulation in vitro, because this requires the presence of thrombomodulin, a thrombin receptor on endothelial cells. The coagulant activity of protein C is species specific and pCa is specifically regulated by protein C inhibitor (pCI) in the presence of heparin.
Normal human plasma contains an average of 0.3 mg/ml. The normal newborn has a protein C level that is 30 to 40% of the normal adult level. Numerous cases with a genetical protein C eficiency associated with thrombotic disease have been reported, frequently with an extensive family history of thrombosis. Patients with a partial protein C deficiency are subject to severe, recurrent deep venous thrombosis and pulmonary embolism. The plasma protein C level should be determined before beginning anticoagulation therapy. Total protein C deficiency in the newborn leads to purpurea fulminans; the diagnosis may be confirmed by determining the protein C levels in both heterozygous parents. Acquired protein C deficiency may result of treatment with oral anticoagulants and of various liver diseases. Plasma protein C levels may also decrease after intravascular coagulation.

General readings

Russell,J.A., (2008) Hum. Genet. 123 (6), 661-663

20 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Protein C / PROC antibody

  Rabbit polyclonal antibody to Protein C (protein C (inactivator of coagulation factors Va and VIIIa))  
Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308939 diluted at 1:3000 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

  Rabbit polyclonal PROC (light chain, Cleaved-Leu179) antibody  
Western blot analysis of extracts from K562 cells, using PROC (light chain, Cleaved-Leu179) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

  Rabbit anti-PROC Polyclonal Antibody  
Western blot analysis of extracts of ES-2 cell lines, using PROC antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Protein C / PROC antibody

Protein C / PROC Mouse IgG2b HLW-C Aff - Purified Hu E
0.5 mg / €420.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Mouse IgG1 CaC-11 Purified Hu E, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Goat Serum Hu ID, IP
1 ml / €440.00
  Acris Antibodies GmbH

Protein C / PROC antibody

Protein C / PROC Sheep Ig Fraction Hu WB
1 ml / €350.00
  Acris Antibodies GmbH

Protein C tag (EDQVDPRLIDGK) antibody

Figure 1. Western blot analysis of anti-Protein-C tag Pab (Cat. #AP11023PU-N)in Protein-C-tagged recombinant protein bacterial lysate. Rabbit Ig Purified WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PROC - human gene knockout kit via CRISPR

PROC - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PROC - human gene knockout kit via CRISPR

PROC - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROC - human gene knockout kit via CRISPR

PROC - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROC - human gene knockout kit via CRISPR

PROC - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Protein C / PROC

  Recombinant protein of human protein C (inactivator of coagulation factors Va and VIIIa) (PROC)  
Protein C / PROC Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PROC overexpression lysate

PROC overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PROC (mGFP-tagged) - Human protein C (inactivator of coagulation factors Va and VIIIa) (PROC), 200 uL, >10^7 TU/mL

Lenti ORF particles, PROC (mGFP-tagged) - Human protein C (inactivator of coagulation factors Va and VIIIa) (PROC), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PROC (Myc-DDK tagged) - Human protein C (inactivator of coagulation factors Va and VIIIa) (PROC) , 200 uL, >10^7 TU/mL

Lenti ORF particles, PROC (Myc-DDK tagged) - Human protein C (inactivator of coagulation factors Va and VIIIa) (PROC) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Proc (GFP-tagged) - Mouse protein C (Proc), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Proc (GFP-tagged) - Mouse protein C (Proc), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Lenti ORF particles, Proc (Myc-DDK-tagged) - Mouse protein C (Proc), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Proc (Myc-DDK-tagged) - Mouse protein C (Proc), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €950.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Proc (GFP-tagged ORF) - Rat protein C (Proc), 200 uL, >10^7 TU/mL

Lenti ORF particles, Proc (GFP-tagged ORF) - Rat protein C (Proc), 200 uL, >10^7 TU/mL  
200 µl / €1,070.00
  OriGene Technologies, Inc.

Lenti ORF particles, Proc (Myc-DDK-tagged ORF) - Rat protein C (Proc), 200 uL, >10^7 TU/mL

Lenti ORF particles, Proc (Myc-DDK-tagged ORF) - Rat protein C (Proc), 200 uL, >10^7 TU/mL  
200 µl / €954.00
  OriGene Technologies, Inc.

20 Item(s)

per page
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