Protein vestigial antibody

Principal name

Protein vestigial antibody

Alternative names for Protein vestigial antibody

vg, CG3830

SwissProt ID


Gene ID

36421 (vg)

Available reactivities

Dros (Drosophila)

Available hosts


Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Protein vestigial antibody

Regulatory genes in insects regulate the conserved signal transduction pathways and provide organ-specific information that is crucial in the development of organs such as wings, eyes and legs. One such gene in Drosophila Melanogaster (fruit flies) is vestigial (vg) (1). Vg, by interacting with other nuclear proteins, is implicated in determining which thoracic imaginal disc cells will form wings and halters (2). Vg, via its interaction with transcription factor scalloped (sd), regulates wing-specific gene expression in Drosophila. This vg-sd interaction forms an active complex that binds to specific DNA sequences and regulates gene expression in cooperation with several signaling pathways (3). Vg gene is activated by dorsoventral organizing signals, Wingless (Wg) and Serrate (Ser). It is even more broadly induced by long-range signaling protein, Decapentaplegic (Dpp) (4). Vg is expressed in the developing wing discs only, not in leg or eye antennal imaginal discs, but it has the ability to reprogram some cells in these imaginal discs to adopt a wing fate (5). Therefore, vg is known as a selector protein for wing identity and development.

A decrease in vg function shifts the dorso-ventral boundary cells of the disc to a cell death sensitive state, and loss of vg function eliminates wing and haltere formation. However, only the TEA domain of scalloped is required for wing development and the rest of the protein is dispensable (6). Ectopic expression of vg in drosophila imaginal discs induces outgrowth and wing tissue specification. Ectopic expression of vg also drives cell cycle progression, induces expression of dE2F1 and its targets, and also dihydrofolate reductase (DHFR) (7). In larval imaginal discs, vg expression is spatially restricted to the presumptive wing and haltere regions. Vg is approximately a 54.4kDa protein (453 amino acids).

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