Prothrombin (F2) antibody

Principal name

Prothrombin (F2) antibody

Alternative names for Prothrombin (F2) antibody

Coagulation factor II

SwissProt ID

P00734 (Human), P00735 (Bovin), P18292 (Rat), P19221 (Mouse), Q19AZ8 (Pig)

Gene ID

2147 (F2), 2155 (F7), 14061, 29251, 100144442

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Ze (Zebrafish), African clawed frog, Xen (Xenopus), GP (Guinea Pig), Rb (Rabbit), Sh (Sheep)

Available hosts

Mouse, Rat, Sheep, Rabbit, Goat, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Radioimmunoassay (R), Immunoprecipitation (IP)

Background of Prothrombin (F2) antibody

Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia.
Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged.
Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.

General readings

1. Kazama et al; Isolation and Characterization of Proteolytic Fragments of Human Factor VIIa Which Inhibit the Tissue Factor-enhanced Amidolytic Activity of Factor
VIIa; The Journal of Biological Chemistry 286(22), pp 16231-16240, 1993.
2. Bharadwaj et al; A Novel Mutation in the Catalytic Domain That Reduces Tissue Factor Binding, Impairs Activation by Factor XA, and Abolishes Amidolytic and Coagulant Activity; JBC 271(48) pp 30685-30691, 1996.
3. Yamamoto et al; Tissue Factor-dependent Autoactivation of Human Blood Coagulation Factor VII; JBC 267(27) 19089-19094, 1992.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Prothrombin (F2) antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between FGA and F2. HeLa cells were stained with anti-FGA rabbit purified polyclonal 1:1200 and anti-F2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG 1B7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Human Liver; Anti-F2 / Thrombin antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.; F2 antibody - middle region (ARP41757_P050) in Human Liver cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Por, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

Prothrombin (F2) antibody

Western blot analysis of extracts from HeLa cells, treated with etoposide (25µM, 24hours), using THRB (AP2, Cleaved-Arg327) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

Western blot analysis on NIH-3T3 cell lysate using THRB Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG2a BDI095 Purified Hu E, WB
0.5 mg / €570.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG1 CaPro-20 Biotin Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG1 CaPro-20 Purified Hu E, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Immunohistochemistry (IHC) analyzes of Prothrombin antibody (Cat.-No. AP01171PU-N) in paraffin-embedded human liver carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Prothrombin (F2) Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Immunofluorescence of purified MaxPab antibody to F2 on HepG2 cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Rabbit Serum Hu IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Western Blot analysis of F2 expression in transfected 293T cell line (H00002147-T01) by F2 MaxPab polyclonal antibody.

Lane 1: F2 transfected lysate(70.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Rat IgG Ms E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG2b 28H5 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Mouse Hu E, R
0.4 mg / €390.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Mouse Hu E, R
0.1 mg / €390.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Rat B131M Ms E, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Sheep Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Sheep Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Prothrombin (F2) antibody

Prothrombin (F2) Rabbit Hu E, R
0.4 mg / €390.00
  Abnova Taiwan Corp.

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