Prothrombin (F2) antibody

Principal name

Prothrombin (F2) antibody

Alternative names for Prothrombin (F2) antibody

Coagulation factor II

SwissProt ID

P00734 (Human), P00735 (Bovin), P18292 (Rat), P19221 (Mouse), Q19AZ8 (Pig)

Gene ID

2147 (F2), 14061, 29251, 100144442

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Sh (Sheep), Rb (Rabbit)

Available hosts

Mouse, Sheep, Rat, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Radioimmunoassay (R), Immunoprecipitation (IP)

Background of Prothrombin (F2) antibody

Prothrombin (Factor 2 in the coagulation cascade) is proteolytically cleaved at two sites by Factor Xa to form thrombin (Factor IIa) in an important step of the coagulation cascade which ultimately results in the stemming of blood loss. Thrombin being the single most important constituent of the coagulation cascade in terms of its feedback activation roles. Prothrombin also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in Prothrombin lead to various forms of thrombosis and dysprothrombinemia.
Prothrombin is a 72 kDa blood clotting glycoprotein formed by and stored in the Liver. Prothrombin is present in the blood plasma and is converted to the key blood clotting agent thrombin, when blood vessels are damaged.
Factor VII, another important haemostasis protein can be converted to VIIa by Factor IXa or Thrombin.

General readings

1. Kazama et al; Isolation and Characterization of Proteolytic Fragments of Human Factor VIIa Which Inhibit the Tissue Factor-enhanced Amidolytic Activity of Factor
VIIa; The Journal of Biological Chemistry 286(22), pp 16231-16240, 1993.
2. Bharadwaj et al; A Novel Mutation in the Catalytic Domain That Reduces Tissue Factor Binding, Impairs Activation by Factor XA, and Abolishes Amidolytic and Coagulant Activity; JBC 271(48) pp 30685-30691, 1996.
3. Yamamoto et al; Tissue Factor-dependent Autoactivation of Human Blood Coagulation Factor VII; JBC 267(27) 19089-19094, 1992.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Prothrombin (F2) antibody

  Rabbit Polyclonal Anti-F2 Antibody  
WB Suggested Anti-F2 Antibody; Titration: 1 ug/ml; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

  Rabbit polyclonal Prothrombin / THRB (AP2, Cleaved-Arg327) antibody  
Western blot analysis of extracts from HeLa cells, treated with etoposide (25µM, 24hours), using THRB (AP2, Cleaved-Arg327) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

  Rabbit Polyclonal Anti-F2 Antibody  
WB Suggested Anti-F2 Antibody; Titration: 1.0 ug/ml; Positive Control: Rat Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

  Rabbit Polyclonal Anti-THRB Antibody  
Western blot analysis on NIH-3T3 cell lysate using THRB Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG2a BDI095 Purified Hu E, WB
0.5 mg / €620.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG1 CaPro-20 Biotin Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Prothrombin (F2) Mouse IgG1 CaPro-20 Purified Hu E, WB
0.2 mg / €450.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Immunohistochemistry (IHC) analyzes of Prothrombin antibody (Cat.-No. AP01171PU-N) in paraffin-embedded human liver carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Prothrombin (F2) antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using THRB Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Prothrombin (F2) antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using THRB Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

Prothrombin (F2) (cleaved) antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide 25uM 24H, using THRB (AP2,Cleaved-Arg327) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

Prothrombin (F2) (cleaved) antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide 25uM 24H, using THRB (AP2,Cleaved-Arg327) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

F2 - human gene knockout kit via CRISPR

F2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

F2 - human gene knockout kit via CRISPR

F2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

F2 - human gene knockout kit via CRISPR

F2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

F2 - human gene knockout kit via CRISPR

F2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

F2 - mouse gene knockout kit via CRISPR

F2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

F2 - mouse gene knockout kit via CRISPR

F2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

F2 - mouse gene knockout kit via CRISPR

F2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

F2 - mouse gene knockout kit via CRISPR

F2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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