PRPF3 antibody

Principal name

PRPF3 antibody

Alternative names for PRPF3 antibody

HPRP3, PRP3, Pre-mRNA-splicing factor 3, U4/U6 snRNP 90 kDa protein, U4/U6 small nuclear ribonucleoprotein Prp3

SwissProt ID

O43395 (Human), Q2KIA6 (Bovin), Q5ZJ85 (Chick), Q922U1 (Mouse)

Gene ID

9129 (PRPF3)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog, Hst (Hamster), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of PRPF3 antibody

Retinitis pigmentosa (RP) is an inheritable disease characterized by progressive retinal degeneration and loss of rod photoreceptor cells, leading to total blindness. Recently three genes responsible for autosomal dominant RP (HPRP3, PRPF31, and PRPC8) have been identified as the human orthologues of the yeast genes PRP3, PRP31, and PRP8, respectively. The removal of introns from nuclear pre-mRNAs occurs on spliceosomes, which consist of 4 small nuclear ribonucleoprotein (snRNP) particles and a number of transiently associated splicing factors. All three PRP (pre-mRNA processing factor) genes are involved in the function of the U4/U6,U5 tri-snRNP, the spliceosome component required for the transition to a catalytically active state. In mammals, the 63 kDa HPRP3 is thought to recruit HPRP4 to the U4/U6 snRNP. In yeast, PRP3 and PRP4 genetically interact, and physical interactions between Prp3p and Prp4p proteins are required for association of Prp3p and Prp4p with U4/U6.

General readings

Rual,J.F., (2005) Nature 437 (7062), 1173-1178

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PRPF3 antibody

  Rabbit anti-PRPF3 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PRPF3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PRPF3 antibody

  Rabbit Polyclonal Anti-PRPF3 Antibody  
WB Suggested Anti-PRPF3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PRPF3 antibody

Immunocytochemical detection of Prp3 on HEp-Ⅱ cells using AM26502AF-N. Rat IgG2a 4E3 Azide Free Hst, Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PRPF3 - human gene knockout kit via CRISPR

PRPF3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PRPF3 - human gene knockout kit via CRISPR

PRPF3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRPF3 - human gene knockout kit via CRISPR

PRPF3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PRPF3 - human gene knockout kit via CRISPR

PRPF3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PRPF3 overexpression lysate

PRPF3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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