PSMA / FOLH1 antibody

Principal name

PSMA / FOLH1 antibody

Alternative names for PSMA / FOLH1 antibody

Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, Pteroylpoly-gamma-glutamate carboxypeptidase, Folylpoly-gamma-glutamate carboxypeptidase

SwissProt ID

O35409 (Mouse), O77564 (Pig), P70627 (Rat), Q04609 (Human)

Gene ID

2346 (FOLH1)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Chk (Chicken), Ms (Mouse), Por (Porcine), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Can (Canine), Mky (Monkey), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F)

Background of PSMA / FOLH1 antibody

FOLH1 is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. A mutation in the gene encoding FOLH1 may be associated with impaired intestinal absorption of dietary folates.It is used as an effective diagnostic and prognostic indicator of prostate cancer.This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.

General readings

Rajasekaran SA, et al., (2008) Mol Cancer Ther 7(7):2142-2151
Polly D.G, et al., (2005) Int J Cancer 116(3):415-421
Susan F.S, et al., (2005) Expert Opin Ther Targets 9(3):561-570

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-FOLH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504752) Mouse IgG1 OTI3H5 Purified Hu, Ms F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMA / FOLH1 (44-750) antibody

Figure 2. Flow Cytometry analysis of GCPII (PSMA) using anti-GCPII (GCP-05) and Goat anti-Mouse-PE on LNCaP cell line (Positive, Green) and HeLa cells (Negative, Blue). Mouse IgG1 GCP-05 Purified Hu F, ICC/IF, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

PSMA / FOLH1 (44-750) antibody

Flow cytometry analysis of GCPII (PSMA) using anti-GCPII (GCP-05) and goat anti-mouse-PE on LNCaP cell line (positive, green) and HeLa cells (negative, blue). Mouse IgG1 GCP-05 PE Hu F
0.1 mg / €400.00
  Acris Antibodies GmbH

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB25, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB25 Purified Can, Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB26, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB26 Purified Hu F, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB27, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB27 Purified Hu F, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB25, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG2b UMAB25 Purified Can, Hu, Mky, Ms, Rt ICC/IF, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB26, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB26 Purified Hu F, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas tissue using anti-FOLH1mouse monoclonal antibody. (Clone UMAB27, dilution 1:100; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB27 Purified Hu F, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

PSMA / FOLH1 antibody

Anti-FOLH1 mouse monoclonal antibody (TA504509) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FOLH1(RC218310). Mouse IgG2b OTI2E1 Purified Can, Hu, Mky, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMA / FOLH1 antibody

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-FOLH1 monoclonal antibody. Mouse IgG1 OTI3E8 Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMA / FOLH1 (C-term) antibody

AM11189PU PSMA antibody staining of Human prostate carcinoma. Rabbit SP29 Supernatant Hu P
0.5 ml / €520.00
  Acris Antibodies GmbH

PSMA / FOLH1 (C-term) antibody

AM11189PU PSMA antibody staining of Human prostate carcinoma. Rabbit SP29 Supernatant Hu P
1 ml / €730.00
  Acris Antibodies GmbH

PSMA / FOLH1 (C-term) antibody

AM11189PU PSMA antibody staining of Human prostate carcinoma. Rabbit SP29 Supernatant Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

PSMA / FOLH1 antibody

AP15751PU PSMA antibody staining of Human Prostate Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

PSMA / FOLH1 antibody

AP15751PU PSMA antibody staining of Human Prostate Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

PSMA / FOLH1 antibody

AP15751PU PSMA antibody staining of Human Prostate Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

PSMA / FOLH1 antibody

WB Suggested Anti-FOLH1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMA / FOLH1 antibody

Host: Rabbit; Target Name: FOLH1; Sample Tissue: RPMI-8226 Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMA / FOLH1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FOLH1 (RC218310, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FOLH1. Mouse IgG1 OTI5A9 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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