PSMB6 antibody

Principal name

PSMB6 antibody

Alternative names for PSMB6 antibody

Proteasome subunit beta type-6, Proteasome 20S beta 6, Macropain delta chain, Proteasome delta chain, Proteasome subunit Y, LMPY, Multicatalytic endopeptidase complex delta chain

SwissProt ID

O43063 (Schpo), P28072 (Human), P28073 (Rat), P38624 (Yeast), Q3MHN0 (Bovin), Q60692 (Mouse), Q8LD27 (Arath)

Gene ID

5694 (PSMB6)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Ze (Zebrafish), African clawed frog, Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PSMB6 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation.
Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelmans syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

General readings

Apcher GS., et al. (2003) FEBS Lett. 553(1-2):200-4.Stelzl U., et al. (2002) Cell. 122(6):957-68.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMB6 antibody

Immunoperoxidase of monoclonal antibody to PSMB6 on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml] Mouse IgG2b S51 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSMB6 antibody

WB Suggested Anti-PSMB6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysatePSMB6 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Can, Hu, Ms, Por, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMB6 antibody

PSMB6 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PSMB6 antibody

Immunoperoxidase of monoclonal antibody to PSMB6 on formalin-fixed paraffin-embedded human lymph node tissue. [antibody concentration sup. ug/ml] Mouse IgG1 2A3-5A8 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSMB6 antibody

Human Jurkat; WB Suggested Anti-PSMB6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate. PSMB6 is supported by BioGPS gene expression data to be expressed in Jurkat.; PSMB6 antibody - N-terminal region (ARP56469_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PSMB6 antibody

PSMB6 Rabbit IgG Hu WB
0.1 ml / €340.00
  Novus Biologicals Inc.

PSMB6 antibody

Western Blot: Proteasome 20S beta 6 Antibody [NBP1-56575] - This Anti-PSMB6 antibody was used in Western Blot of Jurkat     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

PSMB6 antibody

Immunohistochemistry-Paraffin: Proteasome 20S beta 6 Antibody [NBP1-88024] - Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMB6

PSMB6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PSMB6 (35-239, His-tag)

PSMB6 Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

PSMB6 (35-239, His-tag)

PSMB6 Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

PSMB6

PSMB6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMB6

PSMB6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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