PSMB7 antibody

Principal name

PSMB7 antibody

Alternative names for PSMB7 antibody

Proteasome subunit beta type-7, Proteasome 20S beta 7, Macropain chain Z, Proteasome subunit Z, Multicatalytic endopeptidase complex chain Z

SwissProt ID

A1XQU1 (Pig), P25043 (Yeast), P70195 (Mouse), Q09841 (Schpo), Q2TBP0 (Bovin), Q99436 (Human), Q9JHW0 (Rat)

Gene ID

5695 (PSMB7)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Mky (Monkey), Can (Canine)

Available hosts

Rabbit, Mouse, Chicken, Goat

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C)

Background of PSMB7 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. This complex, consisting of alpha, beta, and gamma subunits, enhances the activity of the 20S proteolytic core. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation.
Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelmans syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).

General readings

Wang X., et al. (2007) Biochemistry. 46:3553-3565Rho J.H., et al. (2008) J. Proteome Res. 7:2959-2972

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMB7 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-PSMB7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504368) Mouse IgG1 OTI1E1 Purified Hu, Mky, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-PSMB7 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504429) Mouse IgG2b OTI1D1 Purified Hu, Mky, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

AP21518PU-N PSMB7 antibody staining of HEK293 lysate at 0.3 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

PSMB7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMB7 (RC201799, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMB7. Mouse IgG1 OTI4E10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

Anti-PSMB7 mouse monoclonal antibody (TA504383) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMB7(RC201799). Mouse IgG1 OTI4G9 Purified Can, Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMB7 (RC201799, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMB7. Mouse IgG1 OTI4D12 Purified Hu, Mky, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMB7 (RC201799, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMB7. Mouse IgG1 OTI1B2 Purified Hu, Mky, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 antibody

Anti-PSMB7 mouse monoclonal antibody (TA504638) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMB7(RC201799). Mouse IgG2b OTI4E3 Purified Can, Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMB7 pSer214 antibody

PSMB7 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PSMB7 antibody

PSMB7 Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PSMB7 antibody

Western Blot analysis of PSMB7 expression in transfected 293T cell line (H00005695-T02) by PSMB7 MaxPab polyclonal antibody.

Lane 1: PSMB7 transfected lysate(30.58 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PSMB7 antibody

PSMB7 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

PSMB7 antibody

PSMB7 Goat Aff - Purified Bov, Hu, Ms, Por, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMB7 (full length, N-term HIS tag)

PSMB7 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

PSMB7 (44-277, His-tag)

PSMB7 Human Purified > 80 % by SDS - PAGE E. coli
50 µg / €730.00
  Acris Antibodies GmbH

PSMB7 (44-277, His-tag)

PSMB7 Human Purified > 80 % by SDS - PAGE E. coli
10 µg / €300.00
  Acris Antibodies GmbH

PSMB7

PSMB7 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMB7

PSMB7 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PSMB7

PSMB7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMB7

PSMB7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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