PSMC1 antibody

Principal name

PSMC1 antibody

Alternative names for PSMC1 antibody

26S protease regulatory subunit 4, Proteasome 19S S4, P26s4, Proteasome 26S subunit ATPase 1, 26S proteasome AAA-ATPase subunit RPT2

SwissProt ID

O16368 (Caeel), P36612 (Schpo), P40327 (Yeast), P48601 (Drome), P62191 (Human), P62192 (Mouse), P62193 (Rat), Q90732 (Chick)

Gene ID

5700 (PSMC1), 19179 (Psmc1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ye (Yeast), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PSMC1 antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

General / background references:Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). PubMed PMID: 10073263
Voges D et al. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 68:1015-68 (1999). PubMed PMID: 10872471
Rechsteiner M Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30 (1987). PubMed PMID: 2825735

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMC1 antibody

PRS4 Antibody (C-term) (Cat. #TA325154) western blot analysis in A549,Hela Rabbit IgG Purified Hu, Ms, Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

PSMC1 antibody

WB Suggested Anti-Psmc1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMC1 (C-term) antibody

Mouse Brain; WB Suggested Anti-Psmc1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Brain; Psmc1 antibody - C-terminal region (ARP56476_P050) in Mouse Brain cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

PSMC1 antibody

Western Blot: Proteasome 19S Subunit S4 Antibody [NB120-3317] - Figure 1 shows a Western blot of proteasome 19S subunit S4 on HeLa cell lysate using NB120-3317. Rabbit IgG Purified Hu, Ye IP, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

PSMC1 antibody

Immunohistochemistry-Paraffin: Proteasome 19S S4 Antibody [NBP1-80959] - Immunohistochemical staining of human cerebellum shows strong nuclear positivity in purkinje cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

PSMC1 antibody

Western Blot: PSMC1 Antibody [NBP1-91476] - Mouse brain lysate probed with PSMC1 antibody at a concentration of 1.0 ug/ml. Rabbit Aff - Purified Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMC1

PSMC1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

7 Item(s)

per page
  • LinkedIn