PSMC2 / MSS1 antibody

Principal name

PSMC2 / MSS1 antibody

Alternative names for PSMC2 / MSS1 antibody

26S protease regulatory subunit 7, Proteasome 19S S7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2

SwissProt ID

O42931 (Schpo), P33299 (Yeast), P35998 (Human), P46471 (Mouse), P46472 (Xenla), Q18787 (Caeel), Q5E9F9 (Bovin), Q63347 (Rat), Q9SSB5 (Arath)

Gene ID

5701 (PSMC2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Dros (Drosophila), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PSMC2 / MSS1 antibody

The 26S protease is involved in the ATP-dependent degradation of ubiquitited proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteise complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

General / background references:Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). PubMed PMID: 10073263
Voges D et al. The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem 68:1015-68 (1999). PubMed PMID: 10872471
Rechsteiner M Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30 (1987). PubMed PMID: 2825735

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMC2 / MSS1 antibody

Western blot analysis of extracts of various cell lines, using PSMC2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMC2 / MSS1 antibody

WB Suggested Anti-PSMC2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMC2 / MSS1 antibody

WB Suggested Anti-PSMC2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Can, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMC2 / MSS1 antibody

PSMC2 / MSS1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PSMC2 / MSS1 antibody

Immunofluorescence of monoclonal antibody to PSMC2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG1 4C10-2C8 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSMC2 / MSS1 antibody

Human OVCAR-3; WB Suggested Anti-PSMC2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: OVCAR-3 cell lysate; PSMC2 antibody - N-terminal region (ARP34239_P050) in Human OVCAR-3 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Dros, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PSMC2 / MSS1 antibody

Human Jurkat; WB Suggested Anti-PSMC2 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:1562500. Positive Control: Jurkat cell lysate; PSMC2 antibody - N-terminal region (ARP38189_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

PSMC2 / MSS1 antibody

Western Blot: Proteasome 19S Subunit S7 Antibody [NB120-3322] - Figure 1 shows a Western blot of proteasome 19S subunit S7 on HeLa cell lysate using NB120-3322. Rabbit IgG Purified Hu IP, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

PSMC2 / MSS1 antibody

Immunohistochemistry-Paraffin: Proteasome 19S S7 Antibody [NBP1-87797] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic and nuclear positivity in neuronal cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMC2 / MSS1

PSMC2 / MSS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMC2 / MSS1

PSMC2 / MSS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

11 Item(s)

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