PSMC2 / MSS1 antibody

Principal name

PSMC2 / MSS1 antibody

Alternative names for PSMC2 / MSS1 antibody

26S protease regulatory subunit 7, Proteasome 19S S7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2

SwissProt ID

O42931 (Schpo), P33299 (Yeast), P35998 (Human), P46471 (Mouse), P46472 (Xenla), Q18787 (Caeel), Q5E9F9 (Bovin), Q63347 (Rat), Q9SSB5 (Arath)

Gene ID

5701 (PSMC2), 25581 (Psmc2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Dros (Drosophila), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PSMC2 / MSS1 antibody

The 26S protease is involved in the ATP-dependent degradation of ubiquitited proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, PSMC2 is a positive modulator of Tat-mediated transactivation.The 26S proteasome is a multicatalytic proteise complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Bouwmeester,T., et al., (2004) Nat. Cell Biol. 6 (2), 97-105

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