PSMC5 / SUG1 antibody

Principal name

PSMC5 / SUG1 antibody

Alternative names for PSMC5 / SUG1 antibody

SUG-1, TRIP1, TBP10, p45/SUG, 26S protease regulatory subunit 8, Proteasome subunit p45, Thyroid hormone receptor-interacting protein 1

SwissProt ID

O18413 (Drome), P41836 (Schpo), P46470 (Xenla), P62194 (Bovin), P62195 (Human), P62196 (Mouse), P62197 (Pig), P62198 (Rat), Q01939 (Yeast)

Gene ID

5705 (PSMC5)

Available reactivities

Hu (Human), Bov (Bovine), Ce (C. elegans), Can (Canine), Dros (Drosophila), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), ChIP assay (ChIP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PSMC5 / SUG1 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

General readings

Inoue,T., et al., (2006) Biochem. Biophys. Res. Commun. 342 (3), 829-834

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMC5 / SUG1 antibody

Sample Type: 4. rat brain extract (80ug); Primary Antibody Dilution:  2 ug/ml; Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience; Secondary Antibody Dilution: 1: 20, 000; Image Submitted by: Yuzhi Chen; University of Arkansas for Medical Science; Rabbit IgG Purified Bov, Eq, GP, Hu, Por, Rb, Rt IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMC5 / SUG1 antibody

Human brain; . Sample Type :. Human brain stem cells. Primary Antibody Dilution :. 1:500. Secondary Antibody :. Goat anti-rabbit Alexa-Fluor 594. Secondary Antibody Dilution :. 1:1000. Color/Signal Descriptions :. PSMC5: Red DAPI:Blue. Gene Name :. PSMC5. Submitted by :. Dr. Yuzhi Chen, University of Arkansas for Medical Science; PSMC5 antibody - C-terminal region (ARP38192_T100) in Human brain cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Ce, Dros, Hu, Ms, Por, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

PSMC5 / SUG1 antibody

Immunohistochemistry-Paraffin: SUG1  Antibody [NB100-2572] - FFPE section of human metastatic bone marrow.  Affinity purified rabbit anti-SUG1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit Rabbit Aff - Purified Hu, Ms IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

PSMC5 / SUG1 antibody

Western blot analysis of extracts of A431 cell and HepG2 cell lines, using PSMC5 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMC5 / SUG1 antibody

PSMC5 / SUG1 Rabbit Hu, Ms IP, WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

PSMC5 / SUG1 antibody

Western Blot: PSMC5 Antibody (25D5) [NB100-345] - SUG1 antibody with 30 ug whole cell lysate run on SDS-PAGE. Lane A: 293T; B: A431; C: H1299; D: Hela; E: Hep G2; F: Molt-4; G: Raji Mouse IgG 25D5 Purified Hu ChIP, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

PSMC5 / SUG1 antibody

PSMC5 / SUG1 Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMC5 / SUG1

PSMC5 / SUG1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PSMC5 / SUG1

PSMC5 / SUG1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMC5 / SUG1

PSMC5 / SUG1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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