PSMC6 / SUG2 antibody

Principal name

PSMC6 / SUG2 antibody

Alternative names for PSMC6 / SUG2 antibody

26S protease regulatory subunit 10B, Proteasome 19S 10B, 26S proteasome AAA-ATPase subunit RPT4, Proteasome 26S subunit ATPase 6, Proteasome subunit p42

SwissProt ID

O17071 (Caeel), O74445 (Schpo), P53549 (Yeast), P62333 (Human), P62334 (Mouse), Q2KIW6 (Bovin)

Gene ID

5706 (PSMC6), 173384 (rpt-4)

Available reactivities

Can (Canine), Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Ce (C. elegans), Bov (Bovine), Ze (Zebrafish), Chk (Chicken), Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ye (Yeast)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of PSMC6 / SUG2 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

General readings

Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). PubMed PMID: 10073263

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMC6 / SUG2 antibody

Sample (50 ug of whole cell lysate). A: Mouse brain. 10% SDS PAGE. TA308946 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMC6 / SUG2 antibody

Western blot analysis of extracts of various cell lines, using PSMC6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMC6 / SUG2 antibody

Lanes: 1: 10ug proteasome fraction from C57B1/6J mouse brain, 2: 10ug proteasome fraction from BLAB/C mouse brain; Primary Antibody Dilution: 1:500; Secondary Antibody: Anti-rabbit HRP; Secondary Antibody Dilution: 1:5000; Gene Name: PSMC6; Submitted by: Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMC6 / SUG2 antibody

Immunofluorescence of monoclonal antibody to PSMC6 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2a 2C4 Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSMC6 / SUG2 antibody

Western blot analysis of extracts from RAW264.7 cells, 293 cells and HepG2 cells, using PSMC6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMC6 / SUG2 antibody

PSMC6 / SUG2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PSMC6 / SUG2 antibody

PSMC6 / SUG2 Mouse IgG1 1E5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSMC6 / SUG2 antibody

Western blot analysis of extracts from HepG2/293/RAW264.7 cells, using PSMC6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

PSMC6 / SUG2 antibody

Western blot analysis of extracts from HepG2/293/RAW264.7 cells, using PSMC6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

PSMC6 / SUG2 (C-term) antibody

PSMC6 / SUG2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PSMC6 / SUG2 antibody

Western blot analysis of PSMC6 expression in HEK293 (A); HeLa (B); RAW264.7 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

PSMC6 / SUG2 antibody

Western blot analysis of PSMC6 expression in HEK293 (A); HeLa (B); RAW264.7 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

PSMC6 / SUG2 antibody

Western blot analysis of PSMC6 expression in HEK293 (A); HeLa (B); RAW264.7 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

PSMC6 / SUG2 antibody

Western Blot: Proteasome 19S Subunit S10B Antibody [NB300-532] - Figure 1 shows a Western blot of proteasome 19S subunit S10B in HeLa cell extract using NB300-532. Rabbit Ig Fraction Can, Hu, Ms, Rt WB
0.1 ml / €400.00
  Novus Biologicals Inc.

PSMC6 / SUG2 antibody

Western  Blot: PSMC6 Antibody [NBP1-32403]-(30 ug of whole cell lysate) A: 293T 7.5% SDS PAGE diluted at 1:500 Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMC6 / SUG2

PSMC6 / SUG2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PSMC6 / SUG2

PSMC6 / SUG2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMC6 / SUG2

PSMC6 / SUG2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PSMC6 / SUG2

PSMC6 / SUG2 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

PSMC6 / SUG2

PSMC6 / SUG2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue
10 µg / €380.00
  Abnova Taiwan Corp.

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