PSMD1 antibody

Principal name

PSMD1 antibody

Alternative names for PSMD1 antibody

26S proteasome non-ATPase regulatory subunit 1, 26S proteasome regulatory subunit RPN2, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112

SwissProt ID

O88761 (Rat), Q18115 (Caeel), Q3TXS7 (Mouse), Q5F418 (Chick), Q86VU1 (Human), Q99460 (Human), Q9V3P6 (Drome)

Gene ID

5707 (PSMD1)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of PSMD1 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

General readings

General / background references:Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). PubMed PMID: 10073263
Rechsteiner M Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30 (1987). PubMed PMID: 2825735

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMD1 antibody

WB Suggested Anti-PSMD1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Stomach Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMD1 antibody

WB Suggested Anti-PSMD1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSMD1 antibody

PSMD1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PSMD1 antibody

Human Stomach; WB Suggested Anti-PSMD1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Stomach; PSMD1 antibody - N-terminal region (ARP56477_P050) in Human Stomach cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

PSMD1 antibody

Human Placenta; WB Suggested Anti-PSMD1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Placenta; PSMD1 antibody - N-terminal region (ARP56478_P050) in Human Placenta cells using Western Blot Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PSMD1 19S Subunit S1 antibody

Western Blot: Proteasome 19S Subunit S1 Antibody [NB120-2941] - Figure 1 shows a Western blot of proteasome 19S subunit S1 from HeLa cell extract using NB120-2941. Rabbit IgG Purified Bov, Hu P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PSMD1 antibody

Western Blot: Rpn2 Antibody [NBP1-58214] - This Anti-PSMD1 antibody was used in Western Blot of Fetal Stomach tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

PSMD1 antibody

Western Blot: Rpn2 Antibody [NBP1-58221] - This Anti-PSMD1 antibody was used in Western Blot of Placenta     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSMD1

PSMD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PSMD1

PSMD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PSMD1 overexpression lysate

PSMD1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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