PSMD2 / TRAP2 antibody

Principal name

PSMD2 / TRAP2 antibody

Alternative names for PSMD2 / TRAP2 antibody

26S proteasome non-ATPase regulatory subunit 2, Proteasome 19S S2, 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, Tumor necrosis factor type 1 receptor-associated protein 2

SwissProt ID

P56701 (Bovin), Q13200 (Human), Q4FZT9 (Rat), Q8VDM4 (Mouse)

Gene ID

5708 (PSMD2)

Available reactivities

Hu (Human), Chimp (Chimpanzee), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Luminex (LMNX)

Background of PSMD2 / TRAP2 antibody

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

General readings

Kuai J, Wooters J, Hall JP, Rao VR, Nickbarg E, Li B, Chatterjee-Kishore M, Qiu Y, Lin LL. NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. J Biol Chem. 2004 Dec 17;279(51):53266-71.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSMD2 / TRAP2 antibody

Western blot analysis of extracts of various cell lines, using PSMD2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PSMD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503217) Mouse IgG2a OTI1G6 Purified Can, Hu, Mky, Ms, Rt ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

PSMD2 Elisa with 1H3 Capture (TA600169) and 1G5 Detection (TA700164) Antibodies. Substrate used: Recombinant Human PSMD2 (TP303204) Mouse IgG1 OTI1H3 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

PSMD2 Elisa with 1A12 Capture (TA600165) and 1G5 Detection (TA700164) Antibodies. Substrate used: Recombinant Human PSMD2 (TP303204) Mouse IgG1 OTI1G5 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

PSMD2 Elisa with 1G6 Capture (TA600164) and 1D1 Detection (TA700165) Antibodies. Substrate used: Recombinant Human PSMD2 (TP303204) Mouse IgG1 OTI1D1 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 (C-term) antibody

TA302978 (0.03 µg/ml) staining of A431 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Chimp, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Western blot analysis of extracts from COLO205 cells and 293 cells, using PSMD2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Western blot analysis of extracts from HT-29 cells, HeLa cells and 293 cells, using PSMD2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Predicted band size: 100 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/300 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Predicted band size: 100 kDa . Positive control: Jurkat cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lane1: Jurkat cell lysate Lysate: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Western blot analysis on COLO205 cell lysate using PSMD2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Western blot analysis on COLO205 cell lysate using PSMD2 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503198) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG2a OTI1G5 Purified Can, Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503218) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG2a OTI1A12 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503219) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG2a OTI1B4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503220) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG2a OTI1B5 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMD2 (RC203204, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMD2. Mouse IgG2a OTI1E7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503229) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG1 OTI1D1 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

Anti-PSMD2 mouse monoclonal antibody (TA503270) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PSMD2(RC203204). Mouse IgG2a OTI1G8 Purified Can, Hu, Mky, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PSMD2 / TRAP2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PSMD2 (RC203204, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PSMD2. Mouse IgG2a OTI1H3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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