PSME2 / REG-beta antibody

Principal name

PSME2 / REG-beta antibody

Alternative names for PSME2 / REG-beta antibody

Proteasome activator, PA28b, PA28beta, Proteasome activator complex subunit 2, Proteasome activator 28 subunit beta, 11S regulator complex subunit beta, Activator of multicatalytic protease subunit 2

SwissProt ID

P97372 (Mouse), Q5E9G3 (Bovin), Q63798 (Rat), Q863Z0 (Pig), Q9UL46 (Human)

Gene ID

5721 (PSME2)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Por (Porcine), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of PSME2 / REG-beta antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

General / background references:Schwartz AL & Ciechanover A The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med 50:57-74 (1999). PubMed PMID: 10073263
Rechsteiner M Ubiquitin-mediated pathways for intracellular proteolysis. Annu Rev Cell Biol 3:1-30 (1987). PubMed PMID: 2825735

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PSME2 / REG-beta (C-term) antibody

TA303227 (0.5µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSME2 / REG-beta antibody

Western blot analysis of extracts of various cell lines, using PSME2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PSME2 / REG-beta antibody

WB Suggested Anti-PSME2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSME2 / REG-beta antibody

WB Suggested Anti-PSME2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PSME2 / REG-beta (Center) antibody

Western blot analysis of PSME2 Antibody (Center) (AP17685PU-N) in HL-60,Hela cell line and mouse liver tissue lysates (35ug/lane).PSME2 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PSME2 / REG-beta (C-term) antibody

Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted withAP17686PU-N PSME2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PSME2 / REG-beta antibody

PSME2 / REG-beta Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PSME2 / REG-beta antibody

Immunofluorescence of purified MaxPab antibody to PSME2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PSME2 / REG-beta antibody

PSME2 MaxPab rabbit polyclonal antibody. Western Blot analysis of PSME2 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PSME2 / REG-beta antibody

Western Blot analysis of PSME2 expression in transfected 293T cell line by PSME2 monoclonal antibody (M01), clone 3F11-1A3.

Lane 1: PSME2 transfected lysate(27.4 KDa).
Lane 2: Non-transfected lysate. Mouse IgG1 3F11-1A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSME2 / REG-beta antibody

Immunoperoxidase of monoclonal antibody to PSME2 on formalin-fixed paraffin-embedded human stomach carcinoma. [antibody concentration 6ug/ml] Mouse IgG2a 1G4 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PSME2 / REG-beta antibody

PSME2 polyclonal antibody ( Cat # PAB7268 ) ( 0.5 µg/ml ) staining of human spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PSME2 / REG-beta (Center) antibody

Transfected 293T; WB Suggested Anti-PSME2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Transfected 293T; PSME2 antibody - middle region (ARP56485_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PSME2 / REG-beta (Center) antibody

Human HepG2; WB Suggested Anti-PSME2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: HepG2 cell lysate; PSME2 antibody - middle region (ARP56486_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PSME2 / REG-beta antibody

Western Blot: PSME2 Antibody [NB100-59752] - NB100-59752 (0.5ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PSME2 / REG-beta antibody

PSME2 / REG-beta Rabbit IgG Purified Hu WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSME2 / REG-beta

PSME2 / REG-beta Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PSME2 / REG-beta (1-239, His-tag)

PSME2 / REG-beta Human Purified > 95 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

PSME2 / REG-beta (1-239, His-tag)

PSME2 / REG-beta Human Purified > 95 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

PSME2 / REG-beta

PSME2 / REG-beta Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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