PSME2 / REG-beta antibody

Principal name

PSME2 / REG-beta antibody

Alternative names for PSME2 / REG-beta antibody

Proteasome activator, PA28b, PA28beta, Proteasome activator complex subunit 2, Proteasome activator 28 subunit beta, 11S regulator complex subunit beta, Activator of multicatalytic protease subunit 2

SwissProt ID

P97372 (Mouse), Q5E9G3 (Bovin), Q63798 (Rat), Q863Z0 (Pig), Q9UL46 (Human)

Gene ID

5721 (PSME2), 19188 (Psme2), 29614

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Bov (Bovine), Por (Porcine), Ze (Zebrafish)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PSME2 / REG-beta antibody

The 26S proteasome is a multicatalytic proteise complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator.The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome,The immunoproteasome, isThe processing of class I MHC peptides.The immunoproteasome contains an alterte regulator, referred to asThe 11S regulator or PA28, that replacesThe 19S regulator. Three subunits (alpha, beta and gamma) ofThe 11S regulator have been identified.This gene encodesThe beta subunit ofThe 11S regulator, one ofThe two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008].

General readings

Brychcy M, Kuckelkorn U, Hausdorf G, Egerer K, Kloetzel PM, Burmester GR, Feist E.
Anti-20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28.
Arthritis Rheum. 2006 Jul;54(7):2175-83.
PMID: 16802355

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PSME2 / REG-beta

  Recombinant protein of human proteasome (prosome, macropain) activator subunit 2 (PA28 beta) (PSME2)  
PSME2 / REG-beta Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PSME2 / REG-beta (1-239, His-tag)

PSME2 / REG-beta Human Purified > 95 % by SDS - PAGE E. coli
0.25 mg / €940.00
  OriGene Technologies GmbH

PSME2 / REG-beta (1-239, His-tag)

PSME2 / REG-beta Human Purified > 95 % by SDS - PAGE E. coli
50 µg / €370.00
  OriGene Technologies GmbH

3 Item(s)

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