PTBP1 (PTB) antibody

Principal name

PTBP1 (PTB) antibody

Alternative names for PTBP1 (PTB) antibody

PPTB-1, Polypyrimidine tract-binding protein 1, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1

SwissProt ID

P17225 (Mouse), P26599 (Human), Q00438 (Rat), Q29099 (Pig), Q8WN55 (Bovin)

Gene ID

5725 (PTBP1), 397461, 29497 (Ptbp1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), Hst (Hamster), Mky (Monkey), Prim (Primate), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of PTBP1 (PTB) antibody

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

General readings

Charlet-B N, Logan P, Singh G, Cooper TA. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell. 2002 Mar;9(3):649-58. PMID: 11931771

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTBP1 (PTB) antibody

  Rabbit anti-PTBP1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PTBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) (4-145) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3H8 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PTBP1 (PTB) (N-term) antibody

  Goat Polyclonal Antibody against PTBP1  
TA302892 (0.1 ug/ml) staining of Human Ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

  Mouse Monoclonal anti-PTBP1 Antibody  
Extracts from human PBMC were resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal antibody against PTBP1 (clone 3H7). Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG1 3H7 Purified Hu P, WB
25 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

  Rabbit Polyclonal Anti-PTBP1 Antibody  
WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Daudi cell lysatePTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Daudi cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

  Rabbit Polyclonal Anti-PTBP1 Antibody  
WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: Jurkat cell lysate; PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) (2-14) antibody

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with PTBP1 antibody AP22533PU-N at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bov, Eq, Hst, Hu, Mky, Ms, Por, Prim, Rt, Ze E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PTBP1 - human gene knockout kit via CRISPR

PTBP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PTBP1 - human gene knockout kit via CRISPR

PTBP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTBP1 - human gene knockout kit via CRISPR

PTBP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTBP1 - human gene knockout kit via CRISPR

PTBP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTBP1 (PTB) (transcript variant 1)

  Recombinant protein of human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1  
PTBP1 (PTB) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PTBP1 (PTB) (transcript variant 2)

  Recombinant protein of human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 2  
PTBP1 (PTB) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PTBP1 overexpression lysate

PTBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

PTBP1 overexpression lysate

PTBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

PTBP1 overexpression lysate

PTBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PTBP1 (mGFP-tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTBP1 (mGFP-tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTBP1 (mGFP-tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTBP1 (mGFP-tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTBP1 (Myc-DDK tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PTBP1 (Myc-DDK tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTBP1 (Myc-DDK tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PTBP1 (Myc-DDK tagged) - Human polypyrimidine tract binding protein 1 (PTBP1), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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