PTBP1 (PTB) antibody

Principal name

PTBP1 (PTB) antibody

Alternative names for PTBP1 (PTB) antibody

PPTB-1, Polypyrimidine tract-binding protein 1, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1

SwissProt ID

P17225 (Mouse), P26599 (Human), Q00438 (Rat), Q29099 (Pig), Q8WN55 (Bovin)

Gene ID

5725 (PTBP1), 397461

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), ELISA (detection) (E(detection))

Background of PTBP1 (PTB) antibody

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

General readings

Charlet-B N, Logan P, Singh G, Cooper TA. Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing. Mol Cell. 2002 Mar;9(3):649-58. PMID: 11931771

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTBP1 (PTB) antibody

Western blot analysis of extracts of various cell lines, using PTBP1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) (4-145) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3H8 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

PTBP1 (PTB) antibody

Immunoperoxidase of monoclonal antibody to PTBP1 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] Mouse IgG1 3H8 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTBP1 (PTB) (N-term) antibody

TA302892 (0.1 ug/ml) staining of Human Ovary lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

Extracts from human PBMC were resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal antibody against PTBP1 (clone 3H7). Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system. Mouse IgG1 3H7 Purified Hu P, WB
25 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Daudi cell lysatePTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Daudi cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: Jurkat cell lysate; PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTBP1 (PTB) antibody

PTBP1 (PTB) Mouse IgG1 SH54 Purified Hu ICC/IF, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

PTBP1 (PTB) (2-14) antibody

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with PTBP1 antibody AP22533PU-N at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bov, Eq, Hst, Hu, Mky, Ms, Por, Prim, Rt, Ze E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PTBP1 (PTB) antibody

Immunofluorescence of purified MaxPab antibody to PTBP1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

PTBP1 (PTB) antibody

Western Blot analysis of PTBP1 expression in transfected 293T cell line (H00005725-T01) by PTBP1 MaxPab polyclonal antibody.

Lane 1: PTBP1 transfected lysate(59.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PTBP1 (PTB) antibody

PTBP1 polyclonal antibody ( Cat # PAB6476 ) staining ( 1 µg/ml ) of Jurkat lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PTBP1 (PTB) antibody

Human Daudi; WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml. Positive Control: Daudi cell lysate. PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Daudi cells.; PTBP1 antibody - N-terminal region (ARP40421_P050) in Human Daudi cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PTBP1 (PTB) antibody

Human Jurkat; WB Suggested Anti-PTBP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Jurkat cell lysate. PTBP1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells.; PTBP1 antibody - middle region (ARP40422_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PTBP1 (PTB) antibody

NB 100-1310 staining (1µg/ml) of Jurkat lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PTBP1 (PTB) antibody

Western Blot: PTBP1 Antibody [NBP1-57123] - This Anti-PTBP1 antibody was used in Western Blot of Daudi tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

PTBP1 (PTB) antibody

Western Blot: PTBP1 Antibody [NBP1-57124] - This Anti-PTBP1 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTBP1 (PTB) (transcript variant 1)

PTBP1 (PTB) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PTBP1 (PTB) (transcript variant 2)

PTBP1 (PTB) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PTBP1 (PTB)

PTBP1 (PTB) Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

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