PTCH1 antibody

Principal name

PTCH1 antibody

Alternative names for PTCH1 antibody

PTCH, PTC1, PTC, Patched 1, Protein patched homolog 1

SwissProt ID

O42335 (Cynpy), Q09614 (Caeel), Q13635 (Human), Q61115 (Mouse), Q90693 (Chick), Q98864 (Danre)

Gene ID

5727 (PTCH1), 30181 (ptch2), 19206 (Ptch1)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Can (Canine), Bt (Bat), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), L (Lizard), Bear, Por (Porcine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Rat, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of PTCH1 antibody

PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud.
Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.

General readings

1. Ju B, Spitsbergen J, Eden CJ, Taylor MR, Chen W.
Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Mol Cancer. 2009 Jun 25;8:40.
PMID: 19555497

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTCH1 antibody

  Patched1 (Patched) mouse monoclonal antibody, clone OTI5C7 (formerly 5C7)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-PTCH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500123) Mouse IgG2b OTI5C7 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

  Rabbit Polyclonal Patched 1 Antibody  
Immunohistochemistry: Patched 1 Antibody - With exception of malignant gliomas, malignant tissues such as in colo-rectal cancer showed in general a moderate to strong cytoplasmic and membranous positivity.  Image was provided courtesy of the Swedish Human Proteome Resource (HPR) Center. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTCH1 (266-280) antibody

Staining of Mouse fetal Kidney lysate using PTCH1 Antibody Cat.-No AP32805PU-N at 2 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTCH1 antibody

  Goat Polyclonal Antibody against PTCH  
TA303124 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTCH1 antibody

  Rabbit Polyclonal Patched 1 Antibody  
Western Blot: Patched 1 Antibody -Analysis of Human PTCH1 in Fetal brain Lysate with anti huPTCH1 at a 1:500 dilution. Rabbit Purified Chk, Hu, Ms, Rt C, E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTCH1 antibody

  Rabbit Polyclonal Anti-PTCH1 Antibody  
WB Suggested Anti-PTCH1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTCH1 antibody

  Rabbit Polyclonal Anti-Patched Antibody  
Western blot analysis on mouse muscle cell lysate using Patched Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTCH1 antibody

  anti-Patched1 (Patched) mouse monoclonal antibody, clone OTI3c2 (formerly 3c2)  
Anti-Patched1 mouse monoclonal antibody (TA500122) immunofluorescent staining of HeLa cells transiently transfected by  pCMV6-ENTRY PTCH1(RC201597) Mouse IgG2b OTI3c2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

  PTCH1 mouse monoclonal antibody, clone OTI1H10 (formerly 1H10)  
Human recombinant protein fragment corresponding to amino acids 770-1027 of human PTCH1 (NP_000255) produced in E.coli. Mouse IgG1 OTI1H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

  PTCH1 mouse monoclonal antibody, clone OTI1H8 (formerly 1H8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTCH1 (RC216999, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTCH1. Mouse IgG1 OTI1H8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

  PTCH1 mouse monoclonal antibody, clone OTI5G9 (formerly 5G9)  
Human recombinant protein fragment corresponding to amino acids 770-1027 of human PTCH1 (NP_000255) produced in E.coli. Mouse IgG1 OTI5G9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

  PTCH1 mouse monoclonal antibody, clone OTI6C10 (formerly 6C10)  
Human recombinant protein fragment corresponding to amino acids 770-1027 of human PTCH1 (NP_000255) produced in E.coli. Mouse IgG1 OTI6C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTCH1 antibody

Immunohistochemistry (IHC) analysis of Patched antibody (Cat.-No.: AP06278PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTCH1 antibody

PTCH1 Goat Aff - Purified Ze E, ICC/IF
0.1 mg / €350.00
  Acris Antibodies GmbH

PTCH1 (C-term) antibody

AP22448PU-N PTCH1 antibody staining of Paraffin Embedded Human Colon at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

PTCH1 (1431-1442) antibody

Immunohistochemistry Image: Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Hst, Hu, L, Mky, Ms, Op, Prim, Rb, Rt E, P
50 µg / €470.00
  Acris Antibodies GmbH

PTCH1 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human Small Intestine stained with PTCH1 antibody Cat.-No AP31827PU-N Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PTCH1 antibody

PTCH1 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PTCH1 antibody

PTCH1 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

PTCH1 antibody

PTCH1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

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