PTENP1 antibody

Principal name

PTENP1 antibody

Alternative names for PTENP1 antibody

Phosphatase and tensin homolog 2, PTH2, PTEN-rs, PTEN2, psiPTEN, Phosphatase and tensin homolog pseudogene 1

SwissProt ID

O43460 (Human)

Ncbi ID

9606

Available reactivities

Hu (Human), Chimp (Chimpanzee), Macaque, Ms (Mouse), Op (Opossum), Rt (Rat), Can (Canine), Ze (Zebrafish), Bov (Bovine), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of PTENP1 antibody

This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

General readings

1. Phillips,R.J., Mestas,J., Gharaee-Kermani,M., Burdick,M.D., Sica,A., Belperio,J.A., Keane,M.P. and Strieter,R.M. (2005) Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J. Biol. Chem. 280 (23), 22473-22481.
2. Baak,J.P., Van Diermen,B., Steinbakk,A., Janssen,E., Skaland,I., Mutter,G.L., Fiane,B. and Lovslett,K. (2005) Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum. Pathol. 36 (5), 555-561.
3. Steck,P.A., Pershouse,M.A., Jasser,S.A., Yung,W.K., Lin,H., Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T., Frye,C., Hu,R., Swedlund,B., Teng,D.H. and Tavtigian,S.V. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15 (4), 356-362.
4. Li,J., Yen,C., Liaw,D., Podsypanina,K., Bose,S., Wang,S.I., Puc,J., Miliaresis,C., Rodgers,L., McCombie,R., Bigner,S.H., Giovanella,B.C., Ittmann,M., Tycko,B., Hibshoosh,H., Wigler,M.H. and Parsons,R. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in
human brain, breast, and prostate cancer. Science 275 (5308), 1943-1947.
5. Kim S.K., Su L.K., Oh Y., Kemp B.L., Hong W.K., Mao L. (1998) Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. Oncogene 16:89-93.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTENP1 antibody

  Rabbit polyclonal anti-PTEN-P1 antibody  
WB using Anti-PTEN-P1 antibody shows detection of endogenous PTEN-P1 in whole cell lysates from human derived cell lines HeLa (lane 4), HEK293 (lane 5) and MCF7 (lane 6). The band at ~55 kDa (arrowhead) corresponds to PTEN-P1. Lanes 1-3 were show the results of staining after the antibody was first pre-incubated with the immunizing peptide. Primary antibody was used at 1:500. IRDye800™ conjugated Gt-a-Rabbit IgG [H&L] MX was used at 1:10000. Rabbit IgG Aff - Purified Can, Chimp, green Pufferfish, Hu, Macaque, Ms, Rt, Ze E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

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