Alternative names for PTENP1 antibody
Phosphatase and tensin homolog 2, PTH2, PTEN-rs, PTEN2, psiPTEN, Phosphatase and tensin homolog pseudogene 1
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))
Background of PTENP1 antibody
This gene (PTENP1) is a highly homologous pseudogene of PTEN. PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
1. Phillips,R.J., Mestas,J., Gharaee-Kermani,M., Burdick,M.D., Sica,A., Belperio,J.A., Keane,M.P. and Strieter,R.M. (2005) Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J. Biol. Chem. 280 (23), 22473-22481.
2. Baak,J.P., Van Diermen,B., Steinbakk,A., Janssen,E., Skaland,I., Mutter,G.L., Fiane,B. and Lovslett,K. (2005) Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression. Hum. Pathol. 36 (5), 555-561.
3. Steck,P.A., Pershouse,M.A., Jasser,S.A., Yung,W.K., Lin,H., Ligon,A.H., Langford,L.A., Baumgard,M.L., Hattier,T., Davis,T., Frye,C., Hu,R., Swedlund,B., Teng,D.H. and Tavtigian,S.V. (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 15 (4), 356-362.
4. Li,J., Yen,C., Liaw,D., Podsypanina,K., Bose,S., Wang,S.I., Puc,J., Miliaresis,C., Rodgers,L., McCombie,R., Bigner,S.H., Giovanella,B.C., Ittmann,M., Tycko,B., Hibshoosh,H., Wigler,M.H. and Parsons,R. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in
human brain, breast, and prostate cancer. Science 275 (5308), 1943-1947.
5. Kim S.K., Su L.K., Oh Y., Kemp B.L., Hong W.K., Mao L. (1998) Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. Oncogene 16:89-93.