PTGES3 / TEBP antibody

Principal name

PTGES3 / TEBP antibody

Alternative names for PTGES3 / TEBP antibody

Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23

SwissProt ID

P83868 (Rat), Q15185 (Human), Q3ZBF7 (Bovin), Q90955 (Chick), Q9R0Q7 (Mouse)

Gene ID

10728 (PTGES3), 56351 (Ptges3), 362809

Available reactivities

Hu (Human), Chk (Chicken), GP (Guinea Pig), Ms (Mouse), Rb (Rabbit), S. cerevisiae (Saccharomyces cerevisiae), Rt (Rat), Bov (Bovine), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PTGES3 / TEBP antibody

p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated hsp90 binding of client proteins (8). Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.

General readings

Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406 (2010).
Lee, J.H., et al. Cancer Lett. 290(1):76-86 (2010).
Chadli, A., et al. J. Biol. Chem. 285(6):4224-4231 (2010).
Woo, S.H., et al. J. Biol. Chem. 284(45):30871-30880 (2009).
Mattila, S., et al. Neuropathology 29(2):156-165 (2009).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTGES3 / TEBP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and thyroid cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PTGES3 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PTGES3 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Western blot analysis of p23 in a human cell line mix at a 1:1000 dilution of the antibody Mouse IgG1 JJ6 Purified Chk, GP, Hu, Ms, Rb, S. cerevisiae E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Western blot analysis of extracts of various cell lines, using PTGES3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4D11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI2F2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PTGES3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA803433) Mouse IgG1 OTI2D2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI1D9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG2a OTI2H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4B3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI3A9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI1H5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

Western blot analysis of p23 in a human cell line mix at a 1:1000 dilution of the antibody Mouse IgG1 JJ6 Purified Chk, GP, Hu, Ms, Rb, S. cerevisiae E, IP, P, WB
25 µg / €190.00
  Acris Antibodies GmbH

PTGES3 / TEBP antibody

Immunohistochemistry (IHC) analyzes of TEBP antibody (Cat.-No.: AP01348PU-N) in paraffin-embedded lung carcinoma tissue . Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTGES3 / TEBP (Center) antibody

Western blot analysis of PTGES3 / TEBP Antibody Cat.-No AP53498PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PTGES3 antibody detected the PTGES3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTGES3 / TEBP antibody

PTGES3 / TEBP Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PTGES3 / TEBP antibody

Immunoperoxidase of monoclonal antibody to PTGES3 on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml] Mouse IgG2a 3H1-2A8 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTGES3 / TEBP antibody

PTGES3 / TEBP Mouse IgG2a 3C6-2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTGES3 / TEBP pSer113 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using TEBP (Phospho-Ser113) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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