PTGES3 / TEBP antibody

Principal name

PTGES3 / TEBP antibody

Alternative names for PTGES3 / TEBP antibody

Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase, Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23

SwissProt ID

P83868 (Rat), Q15185 (Human), Q3ZBF7 (Bovin), Q90955 (Chick), Q9R0Q7 (Mouse)

Gene ID

10728 (PTGES3)

Available reactivities

Chk (Chicken), GP (Guinea Pig), Hu (Human), Ms (Mouse), Rb (Rabbit), S. cerevisiae (Saccharomyces cerevisiae), Rt (Rat), Ye (Yeast), Bov (Bovine), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of PTGES3 / TEBP antibody

p23 is a 23kDa ubiquitous, highly conserved co-chaperone for Hsp90. p23 binds Hsp90 and participates in the folding of a number of cell regulatory proteins. p23 is thought to modulate Hsp90 activity in the last stages of the chaperoning pathway and only binds Hsp90 that is in turn bound to ATP which stablizes this state of Hsp90. p23 is a prominent target in leukemic cell apoptosis and may be an important target for antileukemic treatment. Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP 70 and HSP 90), immunosuppressant binding proteins called immunophilins (the FK 506 binding proteins, FKBP 52 & FKBP 54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP 70, HSP 90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP 90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.

General readings

This product has been used in:Hu J et al. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J 16:59-68 (1997). PubMed PMID: 9009268
Dittmar KD & Pratt WB Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. J Biol Chem 272:13047-54 (1997). PubMed PMID: 9148915
Hutchison KA et al. The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90. J Biol Chem 270:18841-7 (1995). PubMed PMID: 7642537
Johnson JL & Toft DO Binding of p23 and hsp90 during assembly with the progesterone receptor. Mol Endocrinol 9:670-8 (1995). PubMed PMID: 8592513
Johnson JL et al. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol 14:1956-63 (1994). PubMed PMID: 8114727
Johnson JL & Toft DO A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem 269:24989-93 (1994). PubMed PMID: 7929183

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTGES3 / TEBP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon and thyroid cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PTGES3 antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Predicted cell location: Cytoplasm . Positive control: Human colon cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using PTGES3 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Western blot analysis of p23 in a human cell line mix at a 1:1000 dilution of the antibody Mouse IgG1 JJ6 Purified Chk, GP, Hu, Ms, Rb, S. cerevisiae E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

Western blot analysis of extracts of various cell lines, using PTGES3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4D11 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI2F2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-PTGES3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA803433) Mouse IgG1 OTI2D2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI1D9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG2a OTI2H10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4B3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI3A9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI4C10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTGES3 (RC201254, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTGES3. Mouse IgG1 OTI1H5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTGES3 / TEBP antibody

Western blot analysis of p23 in a human cell line mix at a 1:1000 dilution of the antibody Mouse IgG1 JJ6 Purified Chk, GP, Hu, Ms, Rb, S. cerevisiae E, IP, P, WB
25 µg / €190.00
  Acris Antibodies GmbH

PTGES3 / TEBP antibody

Immunohistochemistry (IHC) analyzes of TEBP antibody (Cat.-No.: AP01348PU-N) in paraffin-embedded lung carcinoma tissue . Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTGES3 / TEBP (Center) antibody

Western blot analysis of PTGES3 / TEBP Antibody Cat.-No AP53498PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PTGES3 antibody detected the PTGES3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTGES3 / TEBP antibody

PTGES3 / TEBP Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PTGES3 / TEBP antibody

Immunoperoxidase of monoclonal antibody to PTGES3 on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml] Mouse IgG2a 3H1-2A8 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTGES3 / TEBP antibody

PTGES3 / TEBP Mouse IgG2a 3C6-2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTGES3 / TEBP pSer113 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using TEBP (Phospho-Ser113) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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