PTK6 / BRK antibody

Principal name

PTK6 / BRK antibody

Alternative names for PTK6 / BRK antibody

Tyrosine-protein kinase 6, Breast tumor kinase, Tyrosine-protein kinase BRK

SwissProt ID

Q13882 (Human), Q64434 (Mouse)

Gene ID

5753 (PTK6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Dot blot (Dot)

Background of PTK6 / BRK antibody

Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p19RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p19RhoGAP, which promotes association with RASA1/p12RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways. Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTK6 / BRK antibody

Western blot analysis of Brk in lysates from Jurkat cells (Lane 1,2), 3T3 cells (Lane 3) and rat kidney (Lane 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTK6 / BRK antibody

WB Suggested Anti-PTK6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Eq, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTK6 / BRK antibody

Western blot analysis using PTK6 antibody Cat.-No AM06163SU-N against Hela (1), A549 (2) and MCF-7 (3) cell lysate. Mouse IgG2b 2H12B8 Ascites Hu WB
0.1 ml / €440.00
  Acris Antibodies GmbH

PTK6 / BRK antibody

PTK6 / BRK Mouse IgG1 24B7 Purified Hu WB
0.1 mg / €430.00
  Acris Antibodies GmbH

PTK6 / BRK (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTK6 / BRK antibody

Immunofluorescence of purified MaxPab antibody to PTK6 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

PTK6 / BRK antibody

Immunoperoxidase of monoclonal antibody to PTK6 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3 ug/ml] Mouse IgG2b 2F11 Purified Hu E, P
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTK6 / BRK antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with PTK6 polyclonal antibody ( Cat # PAB3434 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PTK6 / BRK antibody

Western blot analysis of PTK6 expression in lysate from Jurkat cells ( Lane 1 and 2 ) , NIH/3T3 cells ( Lane 3 ) and rat kidney ( Lane 4 ) . Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PTK6 / BRK pTyr447 antibody

Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

PTK6 / BRK pTyr447 antibody

Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

PTK6 / BRK antibody

Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Ab-447) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

PTK6 / BRK antibody

Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Ab-447) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

PTK6 / BRK antibody

Western blot analysis of extracts from LOVO cells, using Breast Tumor Kinase Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

PTK6 / BRK antibody

Western blot analysis of extracts from LOVO cells, using Breast Tumor Kinase Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

PTK6 / BRK antibody

Human HepG2; WB Suggested Anti-PTK6 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: HepG2 cell lysate; PTK6 antibody - middle region (ARP56657_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

PTK6 / BRK antibody

Western Blot: PTK6 Antibody ( 2H12B8) [NB110-60537] - Figure 1: Western blot analysis using anti-human PTK6 monoclonal antibody against truncated PTK6 PTK6 recombinant protein (1), MCF-7 cell lysate (2). Mouse IgG2b 2H12B8 Purified Hu E
0.1 ml / €440.00
  Novus Biologicals Inc.

PTK6 / BRK antibody

Western Blot: Brk Antibody [NBP1-45414] - Western blot analysis of Brk in
lysates from Jurkat ceLLS (lane
1,2), 3T3 cells (Lane 3) and
at kidney (Lane 4). Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PTK6 / BRK antibody

PTK6 / BRK Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

PTK6 / BRK antibody

PTK6 / BRK Rabbit IgG Aff - Purified Hu, Ms E, WB
50 µg / €290.00
  Novus Biologicals Inc.

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